![](/images/graphics-bg.png)
Activation of p47phox as a Mechanism of Bupivacaine-Induced Burst Production of Reactive Oxygen Species and Neural Toxicity
المؤلفون المشاركون
Zhao, Wei
Xu, Shi-Yuan
Li, Le
Li, Fengxian
Li, Yu-jie
Yu, Xu-jiao
Liu, Zi-ting
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-08
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Bupivacaine has been shown to induce neurotoxicity through inducing excessive reactive oxygen species (ROS), but the underlying mechanism remains unclear.
NOX2 is one of the most important sources of ROS in the nervous system, and its activation requires the membrane translocation of subunit p47phox.
However, the role of p47phox in bupivacaine-induced neurotoxicity has not been explored.
In our in vitro study, cultured human SH-SY5Y neuroblastoma cells were treated with 1.5 mM bupivacaine to induce neurotoxicity.
Membrane translocation of p47phox was assessed by measuring the cytosol/membrane ratio of p47phox.
The effects of the NOX inhibitor VAS2870 and p47phox-siRNA on bupivacaine-induced neurotoxicity were investigated.
Furthermore, the effect of VAS2870 on bupivacaine-induced neurotoxicity was assessed in vivo in rats.
All these changes were reversed by pretreatment with VAS2870 or transfection with p47phox-siRNA in SH-SY5Y cells.
Similarly, pretreatment with VAS2870 attenuated bupivacaine-induced neuronal toxicity in rats.
It is concluded that enhancing p47phox membrane translocation is a major mechanism whereby bupivacaine induced neurotoxicity and that pretreatment with VAS2870 or local p47phox gene knockdown attenuated bupivacaine-induced neuronal cell injury.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Li, Yu-jie& Zhao, Wei& Yu, Xu-jiao& Li, Fengxian& Liu, Zi-ting& Li, Le…[et al.]. 2017. Activation of p47phox as a Mechanism of Bupivacaine-Induced Burst Production of Reactive Oxygen Species and Neural Toxicity. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1196210
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Li, Yu-jie…[et al.]. Activation of p47phox as a Mechanism of Bupivacaine-Induced Burst Production of Reactive Oxygen Species and Neural Toxicity. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1196210
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Li, Yu-jie& Zhao, Wei& Yu, Xu-jiao& Li, Fengxian& Liu, Zi-ting& Li, Le…[et al.]. Activation of p47phox as a Mechanism of Bupivacaine-Induced Burst Production of Reactive Oxygen Species and Neural Toxicity. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1196210
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196210
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)