Alcoholic Extract of Eclipta alba Shows In Vitro Antioxidant and Anticancer Activity without Exhibiting Toxicological Effects
المؤلفون المشاركون
Singh, R. K.
Yadav, Navneet Kumar
Hossain, Zakir
Sharma, Chetan
Gayen, Jiaur R.
Arya, K. R.
Arya, Rakesh Kumar
Dev, Kapil
Meena, Sanjeev
Datta, Dipak
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-01-31
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
As per WHO estimates, 80% of people around the world use medicinal plants for the cure and prevention of various diseases including cancer owing to their easy availability and cost effectiveness.
Eclipta alba has long been used in Ayurveda to treat liver diseases, eye ailments, and hair related disorders.
The promising medicinal value of E.
alba prompted us to study the antioxidant, nontoxic, and anticancer potential of its alcoholic extract.
In the current study, we evaluated the in vitro cytotoxic and antioxidant effect of the alcoholic extract of Eclipta alba (AEEA) in multiple cancer cell lines along with control.
We have also evaluated its effect on different in vivo toxicity parameters.
Here, we found that AEEA was found to be most active in most of the cancer cell lines but it significantly induced apoptosis in human breast cancer cell lines by disrupting mitochondrial membrane potential and DNA damage.
Moreover, AEEA treatment inhibited migration in both MCF 7 and MDA-MB-231 cells in a dose dependent manner.
Further, AEEA possesses robust in vitro antioxidant activity along with high total phenolic and flavonoid contents.
In summary, our results indicate that Eclipta alba has enormous potential in complementary and alternative medicine for the treatment of cancer.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Yadav, Navneet Kumar& Arya, Rakesh Kumar& Dev, Kapil& Sharma, Chetan& Hossain, Zakir& Meena, Sanjeev…[et al.]. 2017. Alcoholic Extract of Eclipta alba Shows In Vitro Antioxidant and Anticancer Activity without Exhibiting Toxicological Effects. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1196351
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Yadav, Navneet Kumar…[et al.]. Alcoholic Extract of Eclipta alba Shows In Vitro Antioxidant and Anticancer Activity without Exhibiting Toxicological Effects. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1196351
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Yadav, Navneet Kumar& Arya, Rakesh Kumar& Dev, Kapil& Sharma, Chetan& Hossain, Zakir& Meena, Sanjeev…[et al.]. Alcoholic Extract of Eclipta alba Shows In Vitro Antioxidant and Anticancer Activity without Exhibiting Toxicological Effects. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1196351
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196351
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر