Alcoholic Extract of Eclipta alba Shows In Vitro Antioxidant and Anticancer Activity without Exhibiting Toxicological Effects
Joint Authors
Singh, R. K.
Yadav, Navneet Kumar
Hossain, Zakir
Sharma, Chetan
Gayen, Jiaur R.
Arya, K. R.
Arya, Rakesh Kumar
Dev, Kapil
Meena, Sanjeev
Datta, Dipak
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-31
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
As per WHO estimates, 80% of people around the world use medicinal plants for the cure and prevention of various diseases including cancer owing to their easy availability and cost effectiveness.
Eclipta alba has long been used in Ayurveda to treat liver diseases, eye ailments, and hair related disorders.
The promising medicinal value of E.
alba prompted us to study the antioxidant, nontoxic, and anticancer potential of its alcoholic extract.
In the current study, we evaluated the in vitro cytotoxic and antioxidant effect of the alcoholic extract of Eclipta alba (AEEA) in multiple cancer cell lines along with control.
We have also evaluated its effect on different in vivo toxicity parameters.
Here, we found that AEEA was found to be most active in most of the cancer cell lines but it significantly induced apoptosis in human breast cancer cell lines by disrupting mitochondrial membrane potential and DNA damage.
Moreover, AEEA treatment inhibited migration in both MCF 7 and MDA-MB-231 cells in a dose dependent manner.
Further, AEEA possesses robust in vitro antioxidant activity along with high total phenolic and flavonoid contents.
In summary, our results indicate that Eclipta alba has enormous potential in complementary and alternative medicine for the treatment of cancer.
American Psychological Association (APA)
Yadav, Navneet Kumar& Arya, Rakesh Kumar& Dev, Kapil& Sharma, Chetan& Hossain, Zakir& Meena, Sanjeev…[et al.]. 2017. Alcoholic Extract of Eclipta alba Shows In Vitro Antioxidant and Anticancer Activity without Exhibiting Toxicological Effects. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1196351
Modern Language Association (MLA)
Yadav, Navneet Kumar…[et al.]. Alcoholic Extract of Eclipta alba Shows In Vitro Antioxidant and Anticancer Activity without Exhibiting Toxicological Effects. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1196351
American Medical Association (AMA)
Yadav, Navneet Kumar& Arya, Rakesh Kumar& Dev, Kapil& Sharma, Chetan& Hossain, Zakir& Meena, Sanjeev…[et al.]. Alcoholic Extract of Eclipta alba Shows In Vitro Antioxidant and Anticancer Activity without Exhibiting Toxicological Effects. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1196351
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196351