Low Glucose Concentrations Induce a Similar Inflammatory Response in Monocytes from Type 2 Diabetic Patients and Healthy Subjects
المؤلفون المشاركون
Annunziata, Lapolla
Giovanni, Sartore
Piarulli, Francesco
Sechi, Annalisa
Basso, Daniela
Fogar, Paola
Greco, Eliana
Eugenio, Ragazzi
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-31
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
This study aims to assess the proinflammatory interleukin 1β (IL-1β) and anti-inflammatory IL-10 production by monocytes from 38 patients with type 2 diabetes and 31 controls in different glucose concentrations.
Monocytes were incubated in low (2.5 mmol/L)-, normal (5.0 mmol/L)-, and high (20 mmol/L)-glucose conditions in the presence and absence of lipopolysaccharide (LPS).
Monocytes from both patients and controls only produced a significant increase in IL-1β in low-glucose conditions (p<0.01), and this phenomenon was amplified in the presence of LPS, while it was not seen in normal- or high-glucose conditions, not even in the presence of LPS stimulation.
There was no increase in IL-10 production by monocytes from either diabetic patients or controls using whatever glucose concentrations, except when treated with LPS in normal-glucose conditions.
These findings seem to suggest that low-glucose conditions induce an inflammatory response in monocytes in all individuals, as an intrinsic capacity of this cell line.
On the other hand, monocytes only retain their anti-inflammatory ability in response to known inflammatory stimuli such as LPS, under normal-glucose concentrations.
In conclusion, human monocytes express an inflammatory pattern in low-glucose conditions in vitro.
This response could contribute to explaining the higher cardiovascular risk induced by hypoglycemia in diabetic patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Piarulli, Francesco& Giovanni, Sartore& Sechi, Annalisa& Basso, Daniela& Fogar, Paola& Greco, Eliana…[et al.]. 2017. Low Glucose Concentrations Induce a Similar Inflammatory Response in Monocytes from Type 2 Diabetic Patients and Healthy Subjects. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1196373
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Piarulli, Francesco…[et al.]. Low Glucose Concentrations Induce a Similar Inflammatory Response in Monocytes from Type 2 Diabetic Patients and Healthy Subjects. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1196373
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Piarulli, Francesco& Giovanni, Sartore& Sechi, Annalisa& Basso, Daniela& Fogar, Paola& Greco, Eliana…[et al.]. Low Glucose Concentrations Induce a Similar Inflammatory Response in Monocytes from Type 2 Diabetic Patients and Healthy Subjects. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1196373
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196373
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر