Low Glucose Concentrations Induce a Similar Inflammatory Response in Monocytes from Type 2 Diabetic Patients and Healthy Subjects
Joint Authors
Annunziata, Lapolla
Giovanni, Sartore
Piarulli, Francesco
Sechi, Annalisa
Basso, Daniela
Fogar, Paola
Greco, Eliana
Eugenio, Ragazzi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
This study aims to assess the proinflammatory interleukin 1β (IL-1β) and anti-inflammatory IL-10 production by monocytes from 38 patients with type 2 diabetes and 31 controls in different glucose concentrations.
Monocytes were incubated in low (2.5 mmol/L)-, normal (5.0 mmol/L)-, and high (20 mmol/L)-glucose conditions in the presence and absence of lipopolysaccharide (LPS).
Monocytes from both patients and controls only produced a significant increase in IL-1β in low-glucose conditions (p<0.01), and this phenomenon was amplified in the presence of LPS, while it was not seen in normal- or high-glucose conditions, not even in the presence of LPS stimulation.
There was no increase in IL-10 production by monocytes from either diabetic patients or controls using whatever glucose concentrations, except when treated with LPS in normal-glucose conditions.
These findings seem to suggest that low-glucose conditions induce an inflammatory response in monocytes in all individuals, as an intrinsic capacity of this cell line.
On the other hand, monocytes only retain their anti-inflammatory ability in response to known inflammatory stimuli such as LPS, under normal-glucose concentrations.
In conclusion, human monocytes express an inflammatory pattern in low-glucose conditions in vitro.
This response could contribute to explaining the higher cardiovascular risk induced by hypoglycemia in diabetic patients.
American Psychological Association (APA)
Piarulli, Francesco& Giovanni, Sartore& Sechi, Annalisa& Basso, Daniela& Fogar, Paola& Greco, Eliana…[et al.]. 2017. Low Glucose Concentrations Induce a Similar Inflammatory Response in Monocytes from Type 2 Diabetic Patients and Healthy Subjects. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1196373
Modern Language Association (MLA)
Piarulli, Francesco…[et al.]. Low Glucose Concentrations Induce a Similar Inflammatory Response in Monocytes from Type 2 Diabetic Patients and Healthy Subjects. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-6.
https://search.emarefa.net/detail/BIM-1196373
American Medical Association (AMA)
Piarulli, Francesco& Giovanni, Sartore& Sechi, Annalisa& Basso, Daniela& Fogar, Paola& Greco, Eliana…[et al.]. Low Glucose Concentrations Induce a Similar Inflammatory Response in Monocytes from Type 2 Diabetic Patients and Healthy Subjects. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-6.
https://search.emarefa.net/detail/BIM-1196373
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196373