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Protective Effects of Dinitrosyl Iron Complexes under Oxidative Stress in the Heart
المؤلفون المشاركون
Khapchaev, Asker Y.
Shirinsky, Vladimir P.
Kapelko, Valery I.
Lakomkin, Vladimir L.
Abramov, Alexander A.
Lukoshkova, Elena V.
Undrovinas, Nidas A.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-21
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Background.
Nitric oxide can successfully compete with oxygen for sites of electron-transport chain in conditions of myocardial hypoxia.
These features may prevent excessive oxidative stress occurring in cardiomyocytes during sudden hypoxia-reoxygenation.
Aim.
To study the action of the potent stable NO donor dinitrosyl iron complex with glutathione (Oxacom®) on the recovery of myocardial contractile function and Ca2+ transients in cardiomyocytes during hypoxia-reoxygenation.
Results.
The isolated rat hearts were subjected to 30 min hypoxia followed by 30 min reoxygenation.
The presence of 30 nM Oxacom in hypoxic perfusate reduced myocardial contracture and improved recovery of left ventricular developed pressure partly due to elimination of cardiac arrhythmias.
The same Oxacom concentration limited reactive oxygen species generation in hypoxic cardiomyocytes and increased the viability of isolated cardiomyocytes during hypoxia from 12 to 52% and after reoxygenation from 0 to 40%.
Oxacom prevented hypoxia-induced elevation of diastolic Ca2+ level and eliminated Ca2+ transport alterations manifested by slow Ca2+ removal from the sarcoplasm and delay in cardiomyocyte relaxation.
Conclusion.
The potent stable NO donor preserved cardiomyocyte integrity and improved functional recovery at hypoxia-reoxygenation both in the isolated heart and in cardiomyocytes mainly due to preservation of Ca2+ transport.
Oxacom demonstrates potential for cardioprotection during hypoxia-reoxygenation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kapelko, Valery I.& Lakomkin, Vladimir L.& Abramov, Alexander A.& Lukoshkova, Elena V.& Undrovinas, Nidas A.& Khapchaev, Asker Y.…[et al.]. 2017. Protective Effects of Dinitrosyl Iron Complexes under Oxidative Stress in the Heart. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1196527
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kapelko, Valery I.…[et al.]. Protective Effects of Dinitrosyl Iron Complexes under Oxidative Stress in the Heart. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1196527
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kapelko, Valery I.& Lakomkin, Vladimir L.& Abramov, Alexander A.& Lukoshkova, Elena V.& Undrovinas, Nidas A.& Khapchaev, Asker Y.…[et al.]. Protective Effects of Dinitrosyl Iron Complexes under Oxidative Stress in the Heart. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1196527
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196527
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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