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Protective Effects of Dinitrosyl Iron Complexes under Oxidative Stress in the Heart
Joint Authors
Khapchaev, Asker Y.
Shirinsky, Vladimir P.
Kapelko, Valery I.
Lakomkin, Vladimir L.
Abramov, Alexander A.
Lukoshkova, Elena V.
Undrovinas, Nidas A.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Background.
Nitric oxide can successfully compete with oxygen for sites of electron-transport chain in conditions of myocardial hypoxia.
These features may prevent excessive oxidative stress occurring in cardiomyocytes during sudden hypoxia-reoxygenation.
Aim.
To study the action of the potent stable NO donor dinitrosyl iron complex with glutathione (Oxacom®) on the recovery of myocardial contractile function and Ca2+ transients in cardiomyocytes during hypoxia-reoxygenation.
Results.
The isolated rat hearts were subjected to 30 min hypoxia followed by 30 min reoxygenation.
The presence of 30 nM Oxacom in hypoxic perfusate reduced myocardial contracture and improved recovery of left ventricular developed pressure partly due to elimination of cardiac arrhythmias.
The same Oxacom concentration limited reactive oxygen species generation in hypoxic cardiomyocytes and increased the viability of isolated cardiomyocytes during hypoxia from 12 to 52% and after reoxygenation from 0 to 40%.
Oxacom prevented hypoxia-induced elevation of diastolic Ca2+ level and eliminated Ca2+ transport alterations manifested by slow Ca2+ removal from the sarcoplasm and delay in cardiomyocyte relaxation.
Conclusion.
The potent stable NO donor preserved cardiomyocyte integrity and improved functional recovery at hypoxia-reoxygenation both in the isolated heart and in cardiomyocytes mainly due to preservation of Ca2+ transport.
Oxacom demonstrates potential for cardioprotection during hypoxia-reoxygenation.
American Psychological Association (APA)
Kapelko, Valery I.& Lakomkin, Vladimir L.& Abramov, Alexander A.& Lukoshkova, Elena V.& Undrovinas, Nidas A.& Khapchaev, Asker Y.…[et al.]. 2017. Protective Effects of Dinitrosyl Iron Complexes under Oxidative Stress in the Heart. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1196527
Modern Language Association (MLA)
Kapelko, Valery I.…[et al.]. Protective Effects of Dinitrosyl Iron Complexes under Oxidative Stress in the Heart. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1196527
American Medical Association (AMA)
Kapelko, Valery I.& Lakomkin, Vladimir L.& Abramov, Alexander A.& Lukoshkova, Elena V.& Undrovinas, Nidas A.& Khapchaev, Asker Y.…[et al.]. Protective Effects of Dinitrosyl Iron Complexes under Oxidative Stress in the Heart. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1196527
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196527