![](/images/graphics-bg.png)
Low-Dose Ionizing Radiation Affects Mesenchymal Stem Cells via Extracellular Oxidized Cell-Free DNA: A Possible Mediator of Bystander Effect and Adaptive Response
المؤلفون المشاركون
Ermakov, Aleksei V.
Izevskaya, Vera L.
Ershova, Elizaveta
Veiko, Natalia
Kutsev, S. I.
Kaliyanov, Andrew A.
Sergeeva, Vasilina A.
Malinovskaya, E. M.
Kameneva, L. V.
Stukalov, S. V.
Dolgikh, O. A.
Veiko, V. P.
Konkova, Marina S.
Kostyuk, Svetlana V.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-22، 22ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-22
دولة النشر
مصر
عدد الصفحات
22
التخصصات الرئيسية
الملخص EN
We have hypothesized that the adaptive response to low doses of ionizing radiation (IR) is mediated by oxidized cell-free DNA (cfDNA) fragments.
Here, we summarize our experimental evidence for this model.
Studies involving measurements of ROS, expression of the NOX (superoxide radical production), induction of apoptosis and DNA double-strand breaks, antiapoptotic gene expression and cell cycle inhibition confirm this hypothesis.
We have demonstrated that treatment of mesenchymal stem cells (MSCs) with low doses of IR (10 cGy) leads to cell death of part of cell population and release of oxidized cfDNA.
cfDNA has the ability to penetrate into the cytoplasm of other cells.
Oxidized cfDNA, like low doses of IR, induces oxidative stress, ROS production, ROS-induced oxidative modifications of nuclear DNA, DNA breaks, arrest of the cell cycle, activation of DNA reparation and antioxidant response, and inhibition of apoptosis.
The MSCs pretreated with low dose of irradiation or oxidized cfDNA were equally effective in induction of adaptive response to challenge further dose of radiation.
Our studies suggest that oxidized cfDNA is a signaling molecule in the stress signaling that mediates radiation-induced bystander effects and that it is an important component of the development of radioadaptive responses to low doses of IR.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sergeeva, Vasilina A.& Ershova, Elizaveta& Veiko, Natalia& Malinovskaya, E. M.& Kaliyanov, Andrew A.& Kameneva, L. V.…[et al.]. 2017. Low-Dose Ionizing Radiation Affects Mesenchymal Stem Cells via Extracellular Oxidized Cell-Free DNA: A Possible Mediator of Bystander Effect and Adaptive Response. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-22.
https://search.emarefa.net/detail/BIM-1196580
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sergeeva, Vasilina A.…[et al.]. Low-Dose Ionizing Radiation Affects Mesenchymal Stem Cells via Extracellular Oxidized Cell-Free DNA: A Possible Mediator of Bystander Effect and Adaptive Response. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-22.
https://search.emarefa.net/detail/BIM-1196580
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sergeeva, Vasilina A.& Ershova, Elizaveta& Veiko, Natalia& Malinovskaya, E. M.& Kaliyanov, Andrew A.& Kameneva, L. V.…[et al.]. Low-Dose Ionizing Radiation Affects Mesenchymal Stem Cells via Extracellular Oxidized Cell-Free DNA: A Possible Mediator of Bystander Effect and Adaptive Response. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-22.
https://search.emarefa.net/detail/BIM-1196580
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196580
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)