Efficacy and Safety of Bevacizumab in the Treatment of Pterygium: An Updated Meta-Analysis of Randomized Controlled Trials
المؤلفون المشاركون
Sun, Yi
Zhang, Bowen
Deng, Juan
Ling, Shiqi
Xiu-Hua, Jia
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-09-05
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Purpose.
Studies investigating efficacy and safety of bevacizumab in pterygium have increased and reported controversial results.
Thus, we updated this meta-analysis to clarify the issue.
Methods.
Studies were selected through search of the databases Embase, PubMed, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) from their inception up until June 2017.
The pooled risk ratio (RR) and 95% confidence interval (CI) were calculated for recurrence and complication rates by using random effects model.
Results.
1045 eyes in 18 randomized controlled trials (RCTs) enrolled.
Overall, the pooled estimate showed a statistically significant effect of bevacizumab on the reduction of recurrence (RR 0.74, 95% CI 0.56–0.97, P=0.03).
Subgroup analyses presented significant results beneficial to bevacizumab (primary pterygium group, RR 0.53, 95% CI 0.33–0.83, P=0.006; conjunctival autograft group, RR 0.48, 95% CI 0.25–0.91, P=0.02; and follow-up longer than 12 months group, RR 0.36, 95% CI 0.13–0.99, P=0.05).
No statistically significant difference was observed in complication rates.
Conclusions.
Application of bevacizumab showed a statistically significant decrease in recurrence rate following removal of primary pterygia, or in cases with conjunctival autograft, or with follow-up longer than 12 months, while complications were not increased.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Sun, Yi& Zhang, Bowen& Xiu-Hua, Jia& Ling, Shiqi& Deng, Juan. 2018. Efficacy and Safety of Bevacizumab in the Treatment of Pterygium: An Updated Meta-Analysis of Randomized Controlled Trials. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1196589
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Sun, Yi…[et al.]. Efficacy and Safety of Bevacizumab in the Treatment of Pterygium: An Updated Meta-Analysis of Randomized Controlled Trials. Journal of Ophthalmology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1196589
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Sun, Yi& Zhang, Bowen& Xiu-Hua, Jia& Ling, Shiqi& Deng, Juan. Efficacy and Safety of Bevacizumab in the Treatment of Pterygium: An Updated Meta-Analysis of Randomized Controlled Trials. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1196589
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196589
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر