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Efficacy and Safety of Bevacizumab in the Treatment of Pterygium: An Updated Meta-Analysis of Randomized Controlled Trials
Joint Authors
Sun, Yi
Zhang, Bowen
Deng, Juan
Ling, Shiqi
Xiu-Hua, Jia
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Purpose.
Studies investigating efficacy and safety of bevacizumab in pterygium have increased and reported controversial results.
Thus, we updated this meta-analysis to clarify the issue.
Methods.
Studies were selected through search of the databases Embase, PubMed, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) from their inception up until June 2017.
The pooled risk ratio (RR) and 95% confidence interval (CI) were calculated for recurrence and complication rates by using random effects model.
Results.
1045 eyes in 18 randomized controlled trials (RCTs) enrolled.
Overall, the pooled estimate showed a statistically significant effect of bevacizumab on the reduction of recurrence (RR 0.74, 95% CI 0.56–0.97, P=0.03).
Subgroup analyses presented significant results beneficial to bevacizumab (primary pterygium group, RR 0.53, 95% CI 0.33–0.83, P=0.006; conjunctival autograft group, RR 0.48, 95% CI 0.25–0.91, P=0.02; and follow-up longer than 12 months group, RR 0.36, 95% CI 0.13–0.99, P=0.05).
No statistically significant difference was observed in complication rates.
Conclusions.
Application of bevacizumab showed a statistically significant decrease in recurrence rate following removal of primary pterygia, or in cases with conjunctival autograft, or with follow-up longer than 12 months, while complications were not increased.
American Psychological Association (APA)
Sun, Yi& Zhang, Bowen& Xiu-Hua, Jia& Ling, Shiqi& Deng, Juan. 2018. Efficacy and Safety of Bevacizumab in the Treatment of Pterygium: An Updated Meta-Analysis of Randomized Controlled Trials. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1196589
Modern Language Association (MLA)
Sun, Yi…[et al.]. Efficacy and Safety of Bevacizumab in the Treatment of Pterygium: An Updated Meta-Analysis of Randomized Controlled Trials. Journal of Ophthalmology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1196589
American Medical Association (AMA)
Sun, Yi& Zhang, Bowen& Xiu-Hua, Jia& Ling, Shiqi& Deng, Juan. Efficacy and Safety of Bevacizumab in the Treatment of Pterygium: An Updated Meta-Analysis of Randomized Controlled Trials. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1196589
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196589