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The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage
المؤلفون المشاركون
Da Pozzo, Eleonora
Costa, Barbara
Cavallini, Chiara
Testai, Lara
Martelli, Alma
Calderone, Vincenzo
Martini, Claudia
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-12
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
In recent years, the health-promoting effects of the citrus flavanone naringenin have been examined.
The results have provided evidence for the modulation of some key mechanisms involved in cellular damage by this compound.
In particular, naringenin has been revealed to have protective properties such as an antioxidant effect in cardiometabolic disorders.
Very recently, beneficial effects of naringenin have been demonstrated in old rats.
Because aging has been demonstrated to be directly related to the occurrence of cardiac disorders, in the present study, the ability of naringenin to prevent cardiac cell senescence was investigated.
For this purpose, a cellular model of senescent myocardial cells was set up and evaluated using colorimetric, fluorimetric, and immunometric techniques.
Relevant cellular senescence markers, such as X-gal staining, cell cycle regulator levels, and the percentage of cell cycle-arrested cells, were found to be reduced in the presence of naringenin.
In addition, cardiac markers of aging-induced damage, including radical oxidative species levels, mitochondrial metabolic activity, mitochondrial calcium buffer capacity, and estrogenic signaling functions, were also modulated by the compound.
These results suggested that naringenin has antiaging effects on myocardial cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Da Pozzo, Eleonora& Costa, Barbara& Cavallini, Chiara& Testai, Lara& Martelli, Alma& Calderone, Vincenzo…[et al.]. 2017. The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1196590
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Da Pozzo, Eleonora…[et al.]. The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1196590
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Da Pozzo, Eleonora& Costa, Barbara& Cavallini, Chiara& Testai, Lara& Martelli, Alma& Calderone, Vincenzo…[et al.]. The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1196590
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196590
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