The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage
Joint Authors
Da Pozzo, Eleonora
Costa, Barbara
Cavallini, Chiara
Testai, Lara
Martelli, Alma
Calderone, Vincenzo
Martini, Claudia
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In recent years, the health-promoting effects of the citrus flavanone naringenin have been examined.
The results have provided evidence for the modulation of some key mechanisms involved in cellular damage by this compound.
In particular, naringenin has been revealed to have protective properties such as an antioxidant effect in cardiometabolic disorders.
Very recently, beneficial effects of naringenin have been demonstrated in old rats.
Because aging has been demonstrated to be directly related to the occurrence of cardiac disorders, in the present study, the ability of naringenin to prevent cardiac cell senescence was investigated.
For this purpose, a cellular model of senescent myocardial cells was set up and evaluated using colorimetric, fluorimetric, and immunometric techniques.
Relevant cellular senescence markers, such as X-gal staining, cell cycle regulator levels, and the percentage of cell cycle-arrested cells, were found to be reduced in the presence of naringenin.
In addition, cardiac markers of aging-induced damage, including radical oxidative species levels, mitochondrial metabolic activity, mitochondrial calcium buffer capacity, and estrogenic signaling functions, were also modulated by the compound.
These results suggested that naringenin has antiaging effects on myocardial cells.
American Psychological Association (APA)
Da Pozzo, Eleonora& Costa, Barbara& Cavallini, Chiara& Testai, Lara& Martelli, Alma& Calderone, Vincenzo…[et al.]. 2017. The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1196590
Modern Language Association (MLA)
Da Pozzo, Eleonora…[et al.]. The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1196590
American Medical Association (AMA)
Da Pozzo, Eleonora& Costa, Barbara& Cavallini, Chiara& Testai, Lara& Martelli, Alma& Calderone, Vincenzo…[et al.]. The Citrus Flavanone Naringenin Protects Myocardial Cells against Age-Associated Damage. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1196590
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196590