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Methylglyoxal Induces Changes in the Glyoxalase System and Impairs Glutamate Uptake Activity in Primary Astrocytes
المؤلفون المشاركون
Galland, Fabiana
Leite, Marina Concli
Hansen, Fernanda
Lirio, Franciane
de Souza, Daniela Fraga
Da Ré, Carollina
Pacheco, Rafaela Ferreira
Vizuete, Adriana Fernanda
Quincozes-Santos, André
Gonçalves, Carlos Alberto
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-08
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
The impairment of astrocyte functions is associated with diabetes mellitus and other neurodegenerative diseases.
Astrocytes have been proposed to be essential cells for neuroprotection against elevated levels of methylglyoxal (MG), a highly reactive aldehyde derived from the glycolytic pathway.
MG exposure impairs primary astrocyte viability, as evaluated by different assays, and these cells respond to MG elevation by increasing glyoxalase 1 activity and glutathione levels, which improve cell viability and survival.
However, C6 glioma cells have shown strong signs of resistance against MG, without significant changes in the glyoxalase system.
Results for aminoguanidine coincubation support the idea that MG toxicity is mediated by glycation.
We found a significant decrease in glutamate uptake by astrocytes, without changes in the expression of the major transporters.
Carbenoxolone, a nonspecific inhibitor of gap junctions, prevented the cytotoxicity induced by MG in astrocyte cultures.
Thus, our data reinforce the idea that astrocyte viability depends on gap junctions and that the impairment induced by MG involves glutamate excitotoxicity.
The astrocyte susceptibility to MG emphasizes the importance of this compound in neurodegenerative diseases, where the neuronal damage induced by MG may be aggravated by the commitment of the cells charged with MG clearance.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hansen, Fernanda& Galland, Fabiana& Lirio, Franciane& de Souza, Daniela Fraga& Da Ré, Carollina& Pacheco, Rafaela Ferreira…[et al.]. 2017. Methylglyoxal Induces Changes in the Glyoxalase System and Impairs Glutamate Uptake Activity in Primary Astrocytes. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1196600
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hansen, Fernanda…[et al.]. Methylglyoxal Induces Changes in the Glyoxalase System and Impairs Glutamate Uptake Activity in Primary Astrocytes. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1196600
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hansen, Fernanda& Galland, Fabiana& Lirio, Franciane& de Souza, Daniela Fraga& Da Ré, Carollina& Pacheco, Rafaela Ferreira…[et al.]. Methylglyoxal Induces Changes in the Glyoxalase System and Impairs Glutamate Uptake Activity in Primary Astrocytes. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1196600
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196600
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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