The Evaluation of Oxidative Stress Parameters in Serum Patients with Relapsing-Remitting Multiple Sclerosis Treated with II-Line Immunomodulatory Therapy
المؤلفون المشاركون
Kasperczyk, Sławomir
Adamczyk-Sowa, Monika
Adamczyk, Bożena
Wawrzyniak, Sławomir
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-12
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objectives.
The assessment of oxidative stress (OS) in serum relapsing-remitting multiple sclerosis patients treated with II-line immunomodulatory therapy (fingolimod, natalizumab) compared to newly diagnosed patients (de novo group) treated with interferon (IFN) beta and controls.
The relationship between OS parameters and gender, age, disease duration, Expanded Disability Status Scale, annualized relapse rate, MRI lesions in patients treated with II-line.
Materials and Methods.
One hundred and twenty-one patients with RRMS were enrolled in the study.
Patients were divided into groups: de novo group, IFN, fingolimod (FG), natalizumab (NT), and controls.
Lipid hydroperoxides (LHP), malondialdehyde (MDA), lipofuscin (LPS), and total oxidative status (TOS) were determined.
Results.
LHP, MDA, and TOS were lower in NT and FG groups compared to the de novo group.
Levels of OS were different between NT and FG patients and the IFN group.
Women treated with FG and NT had lower MDA, LPH, and TOS than women who were not treated while in men only LPH was lowered.
Positive correlations were found between MDA, LHP, TOS, and ARR in the NT group.
Conclusion.
The II-line immunomodulatory treatment decreased OS particularly among women.
No difference in OS levels was observed between II-line therapy and IFN beta.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Adamczyk, Bożena& Wawrzyniak, Sławomir& Kasperczyk, Sławomir& Adamczyk-Sowa, Monika. 2017. The Evaluation of Oxidative Stress Parameters in Serum Patients with Relapsing-Remitting Multiple Sclerosis Treated with II-Line Immunomodulatory Therapy. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1196604
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Adamczyk, Bożena…[et al.]. The Evaluation of Oxidative Stress Parameters in Serum Patients with Relapsing-Remitting Multiple Sclerosis Treated with II-Line Immunomodulatory Therapy. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1196604
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Adamczyk, Bożena& Wawrzyniak, Sławomir& Kasperczyk, Sławomir& Adamczyk-Sowa, Monika. The Evaluation of Oxidative Stress Parameters in Serum Patients with Relapsing-Remitting Multiple Sclerosis Treated with II-Line Immunomodulatory Therapy. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1196604
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196604
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر