The Evaluation of Oxidative Stress Parameters in Serum Patients with Relapsing-Remitting Multiple Sclerosis Treated with II-Line Immunomodulatory Therapy
Joint Authors
Kasperczyk, Sławomir
Adamczyk-Sowa, Monika
Adamczyk, Bożena
Wawrzyniak, Sławomir
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Objectives.
The assessment of oxidative stress (OS) in serum relapsing-remitting multiple sclerosis patients treated with II-line immunomodulatory therapy (fingolimod, natalizumab) compared to newly diagnosed patients (de novo group) treated with interferon (IFN) beta and controls.
The relationship between OS parameters and gender, age, disease duration, Expanded Disability Status Scale, annualized relapse rate, MRI lesions in patients treated with II-line.
Materials and Methods.
One hundred and twenty-one patients with RRMS were enrolled in the study.
Patients were divided into groups: de novo group, IFN, fingolimod (FG), natalizumab (NT), and controls.
Lipid hydroperoxides (LHP), malondialdehyde (MDA), lipofuscin (LPS), and total oxidative status (TOS) were determined.
Results.
LHP, MDA, and TOS were lower in NT and FG groups compared to the de novo group.
Levels of OS were different between NT and FG patients and the IFN group.
Women treated with FG and NT had lower MDA, LPH, and TOS than women who were not treated while in men only LPH was lowered.
Positive correlations were found between MDA, LHP, TOS, and ARR in the NT group.
Conclusion.
The II-line immunomodulatory treatment decreased OS particularly among women.
No difference in OS levels was observed between II-line therapy and IFN beta.
American Psychological Association (APA)
Adamczyk, Bożena& Wawrzyniak, Sławomir& Kasperczyk, Sławomir& Adamczyk-Sowa, Monika. 2017. The Evaluation of Oxidative Stress Parameters in Serum Patients with Relapsing-Remitting Multiple Sclerosis Treated with II-Line Immunomodulatory Therapy. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1196604
Modern Language Association (MLA)
Adamczyk, Bożena…[et al.]. The Evaluation of Oxidative Stress Parameters in Serum Patients with Relapsing-Remitting Multiple Sclerosis Treated with II-Line Immunomodulatory Therapy. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1196604
American Medical Association (AMA)
Adamczyk, Bożena& Wawrzyniak, Sławomir& Kasperczyk, Sławomir& Adamczyk-Sowa, Monika. The Evaluation of Oxidative Stress Parameters in Serum Patients with Relapsing-Remitting Multiple Sclerosis Treated with II-Line Immunomodulatory Therapy. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1196604
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196604