![](/images/graphics-bg.png)
Mitochondrial Respiration in Intact Peripheral Blood Mononuclear Cells and Sirtuin 3 Activity in Patients with Movement Disorders
المؤلفون المشاركون
Wysocka, Ewa
Michalak, Slawomir
Rybacka-Mossakowska, Joanna
Ambrosius, Wojciech
Kozubski, Wojciech
Florczak-Wyspiańska, Jolanta
Osztynowicz, Krystyna
Baszczuk, Aleksandra
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-09-10
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Objective.
Mitochondrial dysfunction is considered a unifying pathophysiological explanation for movement disorders.
Sirtuin 3 (SIRT3) exhibits deacetylase activity and antioxidant properties.
The aim of the study was to analyze the mitochondrial respiration in peripheral blood mononuclear cells (PBMCs) and the SIRT3 activity in patients with movement disorders.
Methods.
Mitochondrial respiration was analyzed in intact PBMCs using the ROUTINE, LEAK, electron transfer system (ETS), and residual oxygen consumption (ROX) protocol by means of high-resolution respirometry.
The SIRT3 expression and PBMC activity were measured using fluorometry.
Ultrasound measurements of the echogenicity of the substantia nigra and the diameter of the 3rd ventricle were also performed.
Results.
Patients with movement disorders exhibited a lower ROUTINE respiration than controls (P = 0.0237).
Reduced oxygen fluxes in the LEAK (P=0.033) and ROX (P=0.0486) states were observed in patients with movement disorders compared with controls.
Decreased ROUTINE respiration (P=0.007) and oxygen flux in the LEAK state (P=0.0203) were observed in patients with PD with substantia nigra hyperechogenicity compared with controls.
Decreased SIRT 3 deacetylase activity was found in patients with movement disorders.
Conclusion.
Impaired mitochondrial respiration in intact PBMCs was associated with inhibited SIRT3 activity and neurodegeneration measures evaluated using ultrasound in patients with PD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Michalak, Slawomir& Florczak-Wyspiańska, Jolanta& Rybacka-Mossakowska, Joanna& Ambrosius, Wojciech& Osztynowicz, Krystyna& Baszczuk, Aleksandra…[et al.]. 2017. Mitochondrial Respiration in Intact Peripheral Blood Mononuclear Cells and Sirtuin 3 Activity in Patients with Movement Disorders. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1196658
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Michalak, Slawomir…[et al.]. Mitochondrial Respiration in Intact Peripheral Blood Mononuclear Cells and Sirtuin 3 Activity in Patients with Movement Disorders. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1196658
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Michalak, Slawomir& Florczak-Wyspiańska, Jolanta& Rybacka-Mossakowska, Joanna& Ambrosius, Wojciech& Osztynowicz, Krystyna& Baszczuk, Aleksandra…[et al.]. Mitochondrial Respiration in Intact Peripheral Blood Mononuclear Cells and Sirtuin 3 Activity in Patients with Movement Disorders. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1196658
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196658
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)