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Treatment Effects of Ischemic Stroke by Berberine, Baicalin, and Jasminoidin from Huang-Lian-Jie-Du-Decoction (HLJDD) Explored by an Integrated Metabolomics Approach
المؤلفون المشاركون
Kong, Lingyi
Zhang, Qian
Fu, Xiaowei
Wang, Junsong
Yang, Minghua
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-20، 20ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-08-14
دولة النشر
مصر
عدد الصفحات
20
التخصصات الرئيسية
الملخص EN
Berberine, baicalin, and jasminoidin were major active ingredients of Huang-Lian-Jie-Du-Decoction (HLJDD), a famous prescription of traditional Chinese medicine (TCM), which has been used for the treatment of ischemic stroke.
The aim of the present study was to classify their roles in the treatment effects of ischemic stroke.
A rat model of middle cerebral artery occlusion (MCAO) was constructed to mimic ischemic stroke and treatment effects of berberine, baicalin, and jasminoidin, and HLJDD was assessed by neurologic deficit scoring, infarct volume, histopathology, immunohistochemistry, biochemistry, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blotting.
In addition, the 1H NMR metabolomics approach was used to assess the metabolic profiles, which combined with correlation network analysis successfully revealed metabolic disorders in ischemic stroke concerning the treatment of the three principal compounds from HLJDD for the first time.
The combined results suggested that berberine, baicalin, and jasminoidin are responsible for the effectiveness of HLJDD on the treatment of ischemic stroke by amelioration of abnormal metabolism and regulation of oxidative stress, neuron autophagy, and inflammatory response.
This integrated metabolomics approach showed its potential in understanding the function of complex formulae and clarifying the role of its components in the overall treatment effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhang, Qian& Fu, Xiaowei& Wang, Junsong& Yang, Minghua& Kong, Lingyi. 2017. Treatment Effects of Ischemic Stroke by Berberine, Baicalin, and Jasminoidin from Huang-Lian-Jie-Du-Decoction (HLJDD) Explored by an Integrated Metabolomics Approach. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-20.
https://search.emarefa.net/detail/BIM-1196759
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhang, Qian…[et al.]. Treatment Effects of Ischemic Stroke by Berberine, Baicalin, and Jasminoidin from Huang-Lian-Jie-Du-Decoction (HLJDD) Explored by an Integrated Metabolomics Approach. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-20.
https://search.emarefa.net/detail/BIM-1196759
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhang, Qian& Fu, Xiaowei& Wang, Junsong& Yang, Minghua& Kong, Lingyi. Treatment Effects of Ischemic Stroke by Berberine, Baicalin, and Jasminoidin from Huang-Lian-Jie-Du-Decoction (HLJDD) Explored by an Integrated Metabolomics Approach. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-20.
https://search.emarefa.net/detail/BIM-1196759
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196759
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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