![](/images/graphics-bg.png)
Treatment Effects of Ischemic Stroke by Berberine, Baicalin, and Jasminoidin from Huang-Lian-Jie-Du-Decoction (HLJDD) Explored by an Integrated Metabolomics Approach
Joint Authors
Kong, Lingyi
Zhang, Qian
Fu, Xiaowei
Wang, Junsong
Yang, Minghua
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-14
Country of Publication
Egypt
No. of Pages
20
Main Subjects
Abstract EN
Berberine, baicalin, and jasminoidin were major active ingredients of Huang-Lian-Jie-Du-Decoction (HLJDD), a famous prescription of traditional Chinese medicine (TCM), which has been used for the treatment of ischemic stroke.
The aim of the present study was to classify their roles in the treatment effects of ischemic stroke.
A rat model of middle cerebral artery occlusion (MCAO) was constructed to mimic ischemic stroke and treatment effects of berberine, baicalin, and jasminoidin, and HLJDD was assessed by neurologic deficit scoring, infarct volume, histopathology, immunohistochemistry, biochemistry, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blotting.
In addition, the 1H NMR metabolomics approach was used to assess the metabolic profiles, which combined with correlation network analysis successfully revealed metabolic disorders in ischemic stroke concerning the treatment of the three principal compounds from HLJDD for the first time.
The combined results suggested that berberine, baicalin, and jasminoidin are responsible for the effectiveness of HLJDD on the treatment of ischemic stroke by amelioration of abnormal metabolism and regulation of oxidative stress, neuron autophagy, and inflammatory response.
This integrated metabolomics approach showed its potential in understanding the function of complex formulae and clarifying the role of its components in the overall treatment effects.
American Psychological Association (APA)
Zhang, Qian& Fu, Xiaowei& Wang, Junsong& Yang, Minghua& Kong, Lingyi. 2017. Treatment Effects of Ischemic Stroke by Berberine, Baicalin, and Jasminoidin from Huang-Lian-Jie-Du-Decoction (HLJDD) Explored by an Integrated Metabolomics Approach. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-20.
https://search.emarefa.net/detail/BIM-1196759
Modern Language Association (MLA)
Zhang, Qian…[et al.]. Treatment Effects of Ischemic Stroke by Berberine, Baicalin, and Jasminoidin from Huang-Lian-Jie-Du-Decoction (HLJDD) Explored by an Integrated Metabolomics Approach. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-20.
https://search.emarefa.net/detail/BIM-1196759
American Medical Association (AMA)
Zhang, Qian& Fu, Xiaowei& Wang, Junsong& Yang, Minghua& Kong, Lingyi. Treatment Effects of Ischemic Stroke by Berberine, Baicalin, and Jasminoidin from Huang-Lian-Jie-Du-Decoction (HLJDD) Explored by an Integrated Metabolomics Approach. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-20.
https://search.emarefa.net/detail/BIM-1196759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196759