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Difference in the Vitreal Protein Profiles of Patients with Proliferative Diabetic Retinopathy with and without Intravitreal Conbercept Injection
المؤلفون المشاركون
Zheng, Zhi
Zhu, Dan-dan
Zou, Chen
Zhao, Minjie
Yu, Jingjing
Wang, Yunzhi
She, Xinping
Hu, Yanan
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-19
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Purpose.
To examine the difference in the vitreal protein profiles of patients with proliferative diabetic retinopathy (PDR) with and without preoperative intravitreal conbercept (IVC) treatment.
Methods.
Liquid chromatography-tandem mass spectrometry- (LC-MS/MS-) based proteomic methods were used to determine the protein profiles of the vitreous humor in patients with PDR treated with (IVC group; n=9) and without (PDR group; n=8) preoperative IVC.
Gene ontology (GO) annotation and REACTOME pathway analysis were obtained to overview differentially expressed proteins between each group.
Intravitreal levels of apolipoprotein A-II (APOA2) and ceruloplasmin (CP) were measured using enzyme-linked immunosorbent assays.
Results.
307 proteins were expressed differentially between PDR and IVC groups, including 218 proteins downregulated in response to IVC.
The most notable GO annotations in level 3 and REACTOME pathways describing the differentially expressed proteins were “innate immune response” and “platelet degranulation.” The intravitreal levels of APOA2 and CP were lower in the IVC group than in the PDR group (p<0.01).
Conclusions.
In addition to decreasing the intravitreal vascular endothelial growth factor level, IVC may alter the vitreal protein profile in patients with PDR, with the differentially regulated proteins involved in the immune response, platelet degranulation, complement activation, and inflammation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zou, Chen& Zhao, Minjie& Yu, Jingjing& Zhu, Dan-dan& Wang, Yunzhi& She, Xinping…[et al.]. 2018. Difference in the Vitreal Protein Profiles of Patients with Proliferative Diabetic Retinopathy with and without Intravitreal Conbercept Injection. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1196866
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zou, Chen…[et al.]. Difference in the Vitreal Protein Profiles of Patients with Proliferative Diabetic Retinopathy with and without Intravitreal Conbercept Injection. Journal of Ophthalmology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1196866
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zou, Chen& Zhao, Minjie& Yu, Jingjing& Zhu, Dan-dan& Wang, Yunzhi& She, Xinping…[et al.]. Difference in the Vitreal Protein Profiles of Patients with Proliferative Diabetic Retinopathy with and without Intravitreal Conbercept Injection. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1196866
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196866
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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