Difference in the Vitreal Protein Profiles of Patients with Proliferative Diabetic Retinopathy with and without Intravitreal Conbercept Injection
Joint Authors
Zheng, Zhi
Zhu, Dan-dan
Zou, Chen
Zhao, Minjie
Yu, Jingjing
Wang, Yunzhi
She, Xinping
Hu, Yanan
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Purpose.
To examine the difference in the vitreal protein profiles of patients with proliferative diabetic retinopathy (PDR) with and without preoperative intravitreal conbercept (IVC) treatment.
Methods.
Liquid chromatography-tandem mass spectrometry- (LC-MS/MS-) based proteomic methods were used to determine the protein profiles of the vitreous humor in patients with PDR treated with (IVC group; n=9) and without (PDR group; n=8) preoperative IVC.
Gene ontology (GO) annotation and REACTOME pathway analysis were obtained to overview differentially expressed proteins between each group.
Intravitreal levels of apolipoprotein A-II (APOA2) and ceruloplasmin (CP) were measured using enzyme-linked immunosorbent assays.
Results.
307 proteins were expressed differentially between PDR and IVC groups, including 218 proteins downregulated in response to IVC.
The most notable GO annotations in level 3 and REACTOME pathways describing the differentially expressed proteins were “innate immune response” and “platelet degranulation.” The intravitreal levels of APOA2 and CP were lower in the IVC group than in the PDR group (p<0.01).
Conclusions.
In addition to decreasing the intravitreal vascular endothelial growth factor level, IVC may alter the vitreal protein profile in patients with PDR, with the differentially regulated proteins involved in the immune response, platelet degranulation, complement activation, and inflammation.
American Psychological Association (APA)
Zou, Chen& Zhao, Minjie& Yu, Jingjing& Zhu, Dan-dan& Wang, Yunzhi& She, Xinping…[et al.]. 2018. Difference in the Vitreal Protein Profiles of Patients with Proliferative Diabetic Retinopathy with and without Intravitreal Conbercept Injection. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1196866
Modern Language Association (MLA)
Zou, Chen…[et al.]. Difference in the Vitreal Protein Profiles of Patients with Proliferative Diabetic Retinopathy with and without Intravitreal Conbercept Injection. Journal of Ophthalmology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1196866
American Medical Association (AMA)
Zou, Chen& Zhao, Minjie& Yu, Jingjing& Zhu, Dan-dan& Wang, Yunzhi& She, Xinping…[et al.]. Difference in the Vitreal Protein Profiles of Patients with Proliferative Diabetic Retinopathy with and without Intravitreal Conbercept Injection. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1196866
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196866