Vascular Endothelial Growth Factor, Basic Fibroblast Growth Factor, and Pigment Epithelium-Derived Factor Expression in the Neovascular Iris in Retinal Diseases
المؤلفون المشاركون
Hou, Xianru
Tao, Yong
Hwang, De-Kuang
Miao, Heng
المصدر
العدد
المجلد 2018، العدد 2018 (31 ديسمبر/كانون الأول 2018)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2018-04-11
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Objective.
To determine the expression of cytokines in the iris of patients with neovascular glaucoma (NVG).
Methods.
Patients with NVG associated with proliferative diabetic retinopathy (PDR, group 1) or central retinal vein occlusion (CRVO, group 2) who had undergone surgical treatment were enrolled.
Patients with primary open-angle glaucoma requiring surgical treatment were included in the control group (group 3).
All iris specimens were obtained during trabeculectomy, 7 days after intravitreal injections of ranibizumab.
The messenger RNA (mRNA) and protein levels of three target cytokines—vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and pigment epithelium-derived factor (PEDF)—in the iris were analyzed and compared.
Results.
We included 39 eyes from 39 patients (12, 15, and 12 in groups 1, 2, and 3, resp.).
The protein and mRNA levels of PEDF were higher in two NVG groups.
The protein levels, but not mRNA level, of bFGF were higher in the two NVG groups.
The protein and mRNA levels of VEGF were similar in the three groups.
Conclusions.
The protein level of bFGF increased in the irises of the NVG patients was not expressed by the iris itself, whereas PEDF may be expressed by the iris tissue in these patients.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Miao, Heng& Hou, Xianru& Hwang, De-Kuang& Tao, Yong. 2018. Vascular Endothelial Growth Factor, Basic Fibroblast Growth Factor, and Pigment Epithelium-Derived Factor Expression in the Neovascular Iris in Retinal Diseases. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1196941
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Miao, Heng…[et al.]. Vascular Endothelial Growth Factor, Basic Fibroblast Growth Factor, and Pigment Epithelium-Derived Factor Expression in the Neovascular Iris in Retinal Diseases. Journal of Ophthalmology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1196941
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Miao, Heng& Hou, Xianru& Hwang, De-Kuang& Tao, Yong. Vascular Endothelial Growth Factor, Basic Fibroblast Growth Factor, and Pigment Epithelium-Derived Factor Expression in the Neovascular Iris in Retinal Diseases. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1196941
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1196941
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر