Vascular Endothelial Growth Factor, Basic Fibroblast Growth Factor, and Pigment Epithelium-Derived Factor Expression in the Neovascular Iris in Retinal Diseases
Joint Authors
Hou, Xianru
Tao, Yong
Hwang, De-Kuang
Miao, Heng
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-11
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Objective.
To determine the expression of cytokines in the iris of patients with neovascular glaucoma (NVG).
Methods.
Patients with NVG associated with proliferative diabetic retinopathy (PDR, group 1) or central retinal vein occlusion (CRVO, group 2) who had undergone surgical treatment were enrolled.
Patients with primary open-angle glaucoma requiring surgical treatment were included in the control group (group 3).
All iris specimens were obtained during trabeculectomy, 7 days after intravitreal injections of ranibizumab.
The messenger RNA (mRNA) and protein levels of three target cytokines—vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and pigment epithelium-derived factor (PEDF)—in the iris were analyzed and compared.
Results.
We included 39 eyes from 39 patients (12, 15, and 12 in groups 1, 2, and 3, resp.).
The protein and mRNA levels of PEDF were higher in two NVG groups.
The protein levels, but not mRNA level, of bFGF were higher in the two NVG groups.
The protein and mRNA levels of VEGF were similar in the three groups.
Conclusions.
The protein level of bFGF increased in the irises of the NVG patients was not expressed by the iris itself, whereas PEDF may be expressed by the iris tissue in these patients.
American Psychological Association (APA)
Miao, Heng& Hou, Xianru& Hwang, De-Kuang& Tao, Yong. 2018. Vascular Endothelial Growth Factor, Basic Fibroblast Growth Factor, and Pigment Epithelium-Derived Factor Expression in the Neovascular Iris in Retinal Diseases. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1196941
Modern Language Association (MLA)
Miao, Heng…[et al.]. Vascular Endothelial Growth Factor, Basic Fibroblast Growth Factor, and Pigment Epithelium-Derived Factor Expression in the Neovascular Iris in Retinal Diseases. Journal of Ophthalmology No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1196941
American Medical Association (AMA)
Miao, Heng& Hou, Xianru& Hwang, De-Kuang& Tao, Yong. Vascular Endothelial Growth Factor, Basic Fibroblast Growth Factor, and Pigment Epithelium-Derived Factor Expression in the Neovascular Iris in Retinal Diseases. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1196941
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196941