Deep Brain Stimulation of Hemiparkinsonian Rats with Unipolar and Bipolar Electrodes for up to 6 Weeks: Behavioral Testing of Freely Moving Animals
المؤلفون المشاركون
Badstuebner, Kathrin
Weber, Immo
Tuchscherer, Armin
Gimsa, Ulrike
Gimsa, Jan
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-07-03
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Although the clinical use of deep brain stimulation (DBS) is increasing, its basic mechanisms of action are still poorly understood.
Platinum/iridium electrodes were inserted into the subthalamic nucleus of rats with unilateral 6-OHDA-induced lesions of the medial forebrain bundle.
Six behavioral parameters were compared with respect to their potential to detect DBS effects.
Locomotor function was quantified by (i) apomorphine-induced rotation, (ii) initiation time, (iii) the number of adjusting steps in the stepping test, and (iv) the total migration distance in the open field test.
Sensorimotor neglect and anxiety were quantified by (v) the retrieval bias in the corridor test and (vi) the ratio of migration distance in the center versus in the periphery in the open field test, respectively.
In our setup, unipolar stimulation was found to be more efficient than bipolar stimulation for achieving beneficial long-term DBS effects.
Performance in the apomorphine-induced rotation test showed no improvement after 6 weeks.
DBS reduced the initiation time of the contralateral paw in the stepping test after 3 weeks of DBS followed by 3 weeks without DBS.
Similarly, sensorimotor neglect was improved.
The latter two parameters were found to be most appropriate for judging therapeutic DBS effects.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Badstuebner, Kathrin& Gimsa, Ulrike& Weber, Immo& Tuchscherer, Armin& Gimsa, Jan. 2017. Deep Brain Stimulation of Hemiparkinsonian Rats with Unipolar and Bipolar Electrodes for up to 6 Weeks: Behavioral Testing of Freely Moving Animals. Parkinson’s Disease،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1197074
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Badstuebner, Kathrin…[et al.]. Deep Brain Stimulation of Hemiparkinsonian Rats with Unipolar and Bipolar Electrodes for up to 6 Weeks: Behavioral Testing of Freely Moving Animals. Parkinson’s Disease No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1197074
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Badstuebner, Kathrin& Gimsa, Ulrike& Weber, Immo& Tuchscherer, Armin& Gimsa, Jan. Deep Brain Stimulation of Hemiparkinsonian Rats with Unipolar and Bipolar Electrodes for up to 6 Weeks: Behavioral Testing of Freely Moving Animals. Parkinson’s Disease. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1197074
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1197074
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر