Deep Brain Stimulation of Hemiparkinsonian Rats with Unipolar and Bipolar Electrodes for up to 6 Weeks: Behavioral Testing of Freely Moving Animals
Joint Authors
Badstuebner, Kathrin
Weber, Immo
Tuchscherer, Armin
Gimsa, Ulrike
Gimsa, Jan
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-03
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Although the clinical use of deep brain stimulation (DBS) is increasing, its basic mechanisms of action are still poorly understood.
Platinum/iridium electrodes were inserted into the subthalamic nucleus of rats with unilateral 6-OHDA-induced lesions of the medial forebrain bundle.
Six behavioral parameters were compared with respect to their potential to detect DBS effects.
Locomotor function was quantified by (i) apomorphine-induced rotation, (ii) initiation time, (iii) the number of adjusting steps in the stepping test, and (iv) the total migration distance in the open field test.
Sensorimotor neglect and anxiety were quantified by (v) the retrieval bias in the corridor test and (vi) the ratio of migration distance in the center versus in the periphery in the open field test, respectively.
In our setup, unipolar stimulation was found to be more efficient than bipolar stimulation for achieving beneficial long-term DBS effects.
Performance in the apomorphine-induced rotation test showed no improvement after 6 weeks.
DBS reduced the initiation time of the contralateral paw in the stepping test after 3 weeks of DBS followed by 3 weeks without DBS.
Similarly, sensorimotor neglect was improved.
The latter two parameters were found to be most appropriate for judging therapeutic DBS effects.
American Psychological Association (APA)
Badstuebner, Kathrin& Gimsa, Ulrike& Weber, Immo& Tuchscherer, Armin& Gimsa, Jan. 2017. Deep Brain Stimulation of Hemiparkinsonian Rats with Unipolar and Bipolar Electrodes for up to 6 Weeks: Behavioral Testing of Freely Moving Animals. Parkinson’s Disease،Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1197074
Modern Language Association (MLA)
Badstuebner, Kathrin…[et al.]. Deep Brain Stimulation of Hemiparkinsonian Rats with Unipolar and Bipolar Electrodes for up to 6 Weeks: Behavioral Testing of Freely Moving Animals. Parkinson’s Disease No. 2017 (2017), pp.1-18.
https://search.emarefa.net/detail/BIM-1197074
American Medical Association (AMA)
Badstuebner, Kathrin& Gimsa, Ulrike& Weber, Immo& Tuchscherer, Armin& Gimsa, Jan. Deep Brain Stimulation of Hemiparkinsonian Rats with Unipolar and Bipolar Electrodes for up to 6 Weeks: Behavioral Testing of Freely Moving Animals. Parkinson’s Disease. 2017. Vol. 2017, no. 2017, pp.1-18.
https://search.emarefa.net/detail/BIM-1197074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197074