Puerarin Protects against Cardiac Fibrosis Associated with the Inhibition of TGF-β1Smad2-Mediated Endothelial-to-Mesenchymal Transition
المؤلفون المشاركون
Tang, Qi-Zhu
Zhang, Ning
Wu, Qing-Qing
Xiao, Yang
Jin, Ya-Ge
Yuan, Yuan
Fan, Di
Che, Yan
Wang, Zhao-Peng
Wang, Sha-Sha
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-05-30
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
Background.
Puerarin is a kind of flavonoids and is extracted from Chinese herb Kudzu root.
Puerarin is widely used as an adjuvant therapy in Chinese clinics.
But little is known about its effects on regulating cardiac fibrosis.
Methods.
Mice were subjected to transverse aorta constriction (TAC) for 8 weeks; meanwhile puerarin was given 1 week after TAC.
Cardiac fibrosis was assessed by pathological staining.
The mRNA and protein changes of CD31 and vimentin in both animal and human umbilical vein endothelial cells (HUVECs) models were detected.
Immunofluorescence colocalization of CD31 and vimentin and scratch test were carried out to examine TGF-β1-induced changes in HUVECs.
The agonist and antagonist of peroxisome proliferator-activated receptor-γ (PPAR-γ) were used to explore the underlying mechanism.
Results.
Puerarin mitigated TAC-induced cardiac fibrosis, accompanied with suppressed endothelial-to-mesenchymal transition (EndMT).
The consistent results were achieved in HUVECs model.
TGF-β1/Smad2 signaling pathway was blunted and PPAR-γ expression was upregulated in puerarin-treated mice and HUVECs.
Pioglitazone could reproduce the protective effect in HUVECs, while GW9662 reversed this effect imposed by puerarin.
Conclusion.
Puerarin protected against TAC-induced cardiac fibrosis, and this protective effect may be attributed to the upregulation of PPAR-γ and the inhibition of TGF-β1/Smad2-mediated EndMT.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jin, Ya-Ge& Yuan, Yuan& Wu, Qing-Qing& Zhang, Ning& Fan, Di& Che, Yan…[et al.]. 2017. Puerarin Protects against Cardiac Fibrosis Associated with the Inhibition of TGF-β1Smad2-Mediated Endothelial-to-Mesenchymal Transition. PPAR Research،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1197203
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jin, Ya-Ge…[et al.]. Puerarin Protects against Cardiac Fibrosis Associated with the Inhibition of TGF-β1Smad2-Mediated Endothelial-to-Mesenchymal Transition. PPAR Research No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1197203
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jin, Ya-Ge& Yuan, Yuan& Wu, Qing-Qing& Zhang, Ning& Fan, Di& Che, Yan…[et al.]. Puerarin Protects against Cardiac Fibrosis Associated with the Inhibition of TGF-β1Smad2-Mediated Endothelial-to-Mesenchymal Transition. PPAR Research. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1197203
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1197203
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر