Fatty Acids of CLA-Enriched Egg Yolks Can Induce Transcriptional Activation of Peroxisome Proliferator-Activated Receptors in MCF-7 Breast Cancer Cells

المؤلفون المشاركون

Koronowicz, Aneta A.
Banks, Paula
Master, Adam
Domagała, Dominik
Piasna-Słupecka, Ewelina
Drozdowska, Mariola
Sikora, Elżbieta
Laidler, Piotr

المصدر

PPAR Research

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-03-26

دولة النشر

مصر

عدد الصفحات

12

التخصصات الرئيسية

الأحياء

الملخص EN

In our previous study, we showed that fatty acids from CLA-enriched egg yolks (EFA-CLA) reduced the proliferation of breast cancer cells; however, the molecular mechanisms of their action remain unknown.

In the current study, we used MCF-7 breast cancer cell line to determine the effect of EFA-CLA, as potential ligands for peroxisome proliferator-activated receptors (PPARs), on identified in silico PPAR-responsive genes: BCAR3, TCF20, WT1, ZNF621, and THRB (transcript TRβ2).

Our results showed that EFA-CLA act as PPAR ligands with agonistic activity for all PPAR isoforms, with the highest specificity towards PPARγ.

In conclusion, we propose that EFA-CLA-mediated regulation of PPAR-responsive genes is most likely facilitated by cis9,trans11CLA isomer incorporated in egg yolk.

Notably, EFA-CLA activated PPAR more efficiently than nonenriched FA as well as synthetic CLA isomers.

We also propose that this regulation, at least in part, can be responsible for the observed reduction in the proliferation of MCF-7 cells treated with EFA-CLA.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Koronowicz, Aneta A.& Banks, Paula& Master, Adam& Domagała, Dominik& Piasna-Słupecka, Ewelina& Drozdowska, Mariola…[et al.]. 2017. Fatty Acids of CLA-Enriched Egg Yolks Can Induce Transcriptional Activation of Peroxisome Proliferator-Activated Receptors in MCF-7 Breast Cancer Cells. PPAR Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1197209

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Koronowicz, Aneta A.…[et al.]. Fatty Acids of CLA-Enriched Egg Yolks Can Induce Transcriptional Activation of Peroxisome Proliferator-Activated Receptors in MCF-7 Breast Cancer Cells. PPAR Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1197209

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Koronowicz, Aneta A.& Banks, Paula& Master, Adam& Domagała, Dominik& Piasna-Słupecka, Ewelina& Drozdowska, Mariola…[et al.]. Fatty Acids of CLA-Enriched Egg Yolks Can Induce Transcriptional Activation of Peroxisome Proliferator-Activated Receptors in MCF-7 Breast Cancer Cells. PPAR Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1197209

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1197209