![](/images/graphics-bg.png)
Fatty Acids of CLA-Enriched Egg Yolks Can Induce Transcriptional Activation of Peroxisome Proliferator-Activated Receptors in MCF-7 Breast Cancer Cells
Joint Authors
Koronowicz, Aneta A.
Banks, Paula
Master, Adam
Domagała, Dominik
Piasna-Słupecka, Ewelina
Drozdowska, Mariola
Sikora, Elżbieta
Laidler, Piotr
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In our previous study, we showed that fatty acids from CLA-enriched egg yolks (EFA-CLA) reduced the proliferation of breast cancer cells; however, the molecular mechanisms of their action remain unknown.
In the current study, we used MCF-7 breast cancer cell line to determine the effect of EFA-CLA, as potential ligands for peroxisome proliferator-activated receptors (PPARs), on identified in silico PPAR-responsive genes: BCAR3, TCF20, WT1, ZNF621, and THRB (transcript TRβ2).
Our results showed that EFA-CLA act as PPAR ligands with agonistic activity for all PPAR isoforms, with the highest specificity towards PPARγ.
In conclusion, we propose that EFA-CLA-mediated regulation of PPAR-responsive genes is most likely facilitated by cis9,trans11CLA isomer incorporated in egg yolk.
Notably, EFA-CLA activated PPAR more efficiently than nonenriched FA as well as synthetic CLA isomers.
We also propose that this regulation, at least in part, can be responsible for the observed reduction in the proliferation of MCF-7 cells treated with EFA-CLA.
American Psychological Association (APA)
Koronowicz, Aneta A.& Banks, Paula& Master, Adam& Domagała, Dominik& Piasna-Słupecka, Ewelina& Drozdowska, Mariola…[et al.]. 2017. Fatty Acids of CLA-Enriched Egg Yolks Can Induce Transcriptional Activation of Peroxisome Proliferator-Activated Receptors in MCF-7 Breast Cancer Cells. PPAR Research،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1197209
Modern Language Association (MLA)
Koronowicz, Aneta A.…[et al.]. Fatty Acids of CLA-Enriched Egg Yolks Can Induce Transcriptional Activation of Peroxisome Proliferator-Activated Receptors in MCF-7 Breast Cancer Cells. PPAR Research No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1197209
American Medical Association (AMA)
Koronowicz, Aneta A.& Banks, Paula& Master, Adam& Domagała, Dominik& Piasna-Słupecka, Ewelina& Drozdowska, Mariola…[et al.]. Fatty Acids of CLA-Enriched Egg Yolks Can Induce Transcriptional Activation of Peroxisome Proliferator-Activated Receptors in MCF-7 Breast Cancer Cells. PPAR Research. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1197209
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197209