The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines
المؤلفون المشاركون
Tan, P.-H.
Hung, Kuo-Chuan
Chia, Yuan-Yi
Liu, Chien-Cheng
Feng, Guan-Ming
Tseng, Chia-Chih Alex
Chen, Chih-Chieh
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-04-02
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Light-emitting diode (LED) phototherapy has been reported to relieve pain and enhance tissue repair through several mechanisms.
However, the analgesic effect of LED on incised wounds has never been examined.
Objectives.
We examined the analgesic effect of LED therapy on incision pain and the changes in cyclooxygenase 2 (COX-2), prostaglandin E2 (PGE2), and the proinflammatory cytokines interleukin 6 (IL-6), IL-1β, and tumor necrosis factor α (TNF-α).
Methods.
Rats received LED therapy on incised skin 6 days before incision (L-I group) or 6 days after incision (I-L group) or from 3 days before incision to 3 days after incision (L-I-L group).
Behavioral tests and analysis of skin tissue were performed after LED therapy.
Results.
LED therapy attenuated the decrease in thermal withdrawal latency in all the irradiated groups and the decrease in the mechanical withdrawal threshold in the L-I group only.
The expression levels of COX-2, PGE2, and IL-6 were significantly decreased in the three LED-treated groups, whereas IL-1β and TNF-α were significantly decreased only in the L-I group compared with their levels in the I groups (p<0.05).
Conclusions.
LED therapy provides an analgesic effect and modifies the expression of COX-2, PGE2, and proinflammatory cytokines in incised skin.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chia, Yuan-Yi& Liu, Chien-Cheng& Feng, Guan-Ming& Tseng, Chia-Chih Alex& Hung, Kuo-Chuan& Chen, Chih-Chieh…[et al.]. 2017. The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines. Pain Research and Management،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1197417
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chia, Yuan-Yi…[et al.]. The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines. Pain Research and Management No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1197417
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chia, Yuan-Yi& Liu, Chien-Cheng& Feng, Guan-Ming& Tseng, Chia-Chih Alex& Hung, Kuo-Chuan& Chen, Chih-Chieh…[et al.]. The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines. Pain Research and Management. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1197417
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1197417
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر