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The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines
Joint Authors
Tan, P.-H.
Hung, Kuo-Chuan
Chia, Yuan-Yi
Liu, Chien-Cheng
Feng, Guan-Ming
Tseng, Chia-Chih Alex
Chen, Chih-Chieh
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-04-02
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Light-emitting diode (LED) phototherapy has been reported to relieve pain and enhance tissue repair through several mechanisms.
However, the analgesic effect of LED on incised wounds has never been examined.
Objectives.
We examined the analgesic effect of LED therapy on incision pain and the changes in cyclooxygenase 2 (COX-2), prostaglandin E2 (PGE2), and the proinflammatory cytokines interleukin 6 (IL-6), IL-1β, and tumor necrosis factor α (TNF-α).
Methods.
Rats received LED therapy on incised skin 6 days before incision (L-I group) or 6 days after incision (I-L group) or from 3 days before incision to 3 days after incision (L-I-L group).
Behavioral tests and analysis of skin tissue were performed after LED therapy.
Results.
LED therapy attenuated the decrease in thermal withdrawal latency in all the irradiated groups and the decrease in the mechanical withdrawal threshold in the L-I group only.
The expression levels of COX-2, PGE2, and IL-6 were significantly decreased in the three LED-treated groups, whereas IL-1β and TNF-α were significantly decreased only in the L-I group compared with their levels in the I groups (p<0.05).
Conclusions.
LED therapy provides an analgesic effect and modifies the expression of COX-2, PGE2, and proinflammatory cytokines in incised skin.
American Psychological Association (APA)
Chia, Yuan-Yi& Liu, Chien-Cheng& Feng, Guan-Ming& Tseng, Chia-Chih Alex& Hung, Kuo-Chuan& Chen, Chih-Chieh…[et al.]. 2017. The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines. Pain Research and Management،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1197417
Modern Language Association (MLA)
Chia, Yuan-Yi…[et al.]. The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines. Pain Research and Management No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1197417
American Medical Association (AMA)
Chia, Yuan-Yi& Liu, Chien-Cheng& Feng, Guan-Ming& Tseng, Chia-Chih Alex& Hung, Kuo-Chuan& Chen, Chih-Chieh…[et al.]. The Antinociceptive Effect of Light-Emitting Diode Irradiation on Incised Wounds Is Correlated with Changes in Cyclooxygenase 2 Activity, Prostaglandin E2, and Proinflammatory Cytokines. Pain Research and Management. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1197417
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197417