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A Preliminary Genome-Wide Association Study of Pain-Related Fear: Implications for Orofacial Pain
المؤلفون المشاركون
Neiswanger, Katherine
Shaffer, John R.
Feingold, Eleanor
Weyant, R. J.
Wright, Casey D.
Randall, Cameron L.
Chernus, Jonathan M.
McNeil, Daniel W.
Marazita, Mary L.
Crout, Richard
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-15
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Background.
Acute and chronic orofacial pain can significantly impact overall health and functioning.
Associations between fear of pain and the experience of orofacial pain are well-documented, and environmental, behavioral, and cognitive components of fear of pain have been elucidated.
Little is known, however, regarding the specific genes contributing to fear of pain.
Methods.
A genome-wide association study (GWAS; N=990) was performed to identify plausible genes that may predispose individuals to various levels of fear of pain.
The total score and three subscales (fear of minor, severe, and medical/dental pain) of the Fear of Pain Questionnaire-9 (FPQ-9) were modeled in a variance components modeling framework to test for genetic association with 8.5 M genetic variants across the genome, while adjusting for sex, age, education, and income.
Results.
Three genetic loci were significantly associated with fear of minor pain (8q24.13, 8p21.2, and 6q26; p<5×10-8 for all) near the genes TMEM65, NEFM, NEFL, AGPAT4, and PARK2.
Other suggestive loci were found for the fear of pain total score and each of the FPQ-9 subscales.
Conclusions.
Multiple genes were identified as possible candidates contributing to fear of pain.
The findings may have implications for understanding and treating chronic orofacial pain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Randall, Cameron L.& Wright, Casey D.& Chernus, Jonathan M.& McNeil, Daniel W.& Feingold, Eleanor& Crout, Richard…[et al.]. 2017. A Preliminary Genome-Wide Association Study of Pain-Related Fear: Implications for Orofacial Pain. Pain Research and Management،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1197473
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Randall, Cameron L.…[et al.]. A Preliminary Genome-Wide Association Study of Pain-Related Fear: Implications for Orofacial Pain. Pain Research and Management No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1197473
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Randall, Cameron L.& Wright, Casey D.& Chernus, Jonathan M.& McNeil, Daniel W.& Feingold, Eleanor& Crout, Richard…[et al.]. A Preliminary Genome-Wide Association Study of Pain-Related Fear: Implications for Orofacial Pain. Pain Research and Management. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1197473
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1197473
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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