A Preliminary Genome-Wide Association Study of Pain-Related Fear: Implications for Orofacial Pain
Joint Authors
Neiswanger, Katherine
Shaffer, John R.
Feingold, Eleanor
Weyant, R. J.
Wright, Casey D.
Randall, Cameron L.
Chernus, Jonathan M.
McNeil, Daniel W.
Marazita, Mary L.
Crout, Richard
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Acute and chronic orofacial pain can significantly impact overall health and functioning.
Associations between fear of pain and the experience of orofacial pain are well-documented, and environmental, behavioral, and cognitive components of fear of pain have been elucidated.
Little is known, however, regarding the specific genes contributing to fear of pain.
Methods.
A genome-wide association study (GWAS; N=990) was performed to identify plausible genes that may predispose individuals to various levels of fear of pain.
The total score and three subscales (fear of minor, severe, and medical/dental pain) of the Fear of Pain Questionnaire-9 (FPQ-9) were modeled in a variance components modeling framework to test for genetic association with 8.5 M genetic variants across the genome, while adjusting for sex, age, education, and income.
Results.
Three genetic loci were significantly associated with fear of minor pain (8q24.13, 8p21.2, and 6q26; p<5×10-8 for all) near the genes TMEM65, NEFM, NEFL, AGPAT4, and PARK2.
Other suggestive loci were found for the fear of pain total score and each of the FPQ-9 subscales.
Conclusions.
Multiple genes were identified as possible candidates contributing to fear of pain.
The findings may have implications for understanding and treating chronic orofacial pain.
American Psychological Association (APA)
Randall, Cameron L.& Wright, Casey D.& Chernus, Jonathan M.& McNeil, Daniel W.& Feingold, Eleanor& Crout, Richard…[et al.]. 2017. A Preliminary Genome-Wide Association Study of Pain-Related Fear: Implications for Orofacial Pain. Pain Research and Management،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1197473
Modern Language Association (MLA)
Randall, Cameron L.…[et al.]. A Preliminary Genome-Wide Association Study of Pain-Related Fear: Implications for Orofacial Pain. Pain Research and Management No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1197473
American Medical Association (AMA)
Randall, Cameron L.& Wright, Casey D.& Chernus, Jonathan M.& McNeil, Daniel W.& Feingold, Eleanor& Crout, Richard…[et al.]. A Preliminary Genome-Wide Association Study of Pain-Related Fear: Implications for Orofacial Pain. Pain Research and Management. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1197473
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197473