Neural Mobilization Treatment Decreases Glial Cells and Brain-Derived Neurotrophic Factor Expression in the Central Nervous System in Rats with Neuropathic Pain Induced by CCI in Rats
المؤلفون المشاركون
Giardini, Aline Carolina
Santos, Fabio Martinez dos
da Silva, Joyce Teixeira
de Oliveira, Mara Evany
Martins, Daniel Oliveira
Chacur, Marucia
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-22
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Glial cells are implicated in the development of chronic pain and brain-derived neurotropic factor (BDNF) released from activated microglia contributes to the nociceptive transmission.
Neural mobilization (NM) technique is a method clinically effective in reducing pain sensitivity.
Here we examined the involvement of glial cells and BDNF expression in the thalamus and midbrain after NM treatment in rats with chronic constriction injury (CCI).
CCI was induced and rats were subsequently submitted to 10 sessions of NM, every other day, beginning 14 days after CCI.
Thalamus and midbrain were analyzed for glial fibrillary acidic protein (GFAP), microglial cell OX-42, and BDNF using Immunohistochemistry and Western blot assays.
Results.
Thalamus and midbrain of CCI group showed increases in GFAP, OX-42, and BDNF expression compared with control group and, in contrast, showed decreases in GFAP, OX-42, and BDNF after NM when compared with CCI group.
The decreased immunoreactivity for GFAP, OX-42, and BDNF in ventral posterolateral nucleus in thalamus and the periaqueductal gray in midbrain was shown by immunohistochemistry.
Conclusions.
These findings may improve the knowledge about the involvement of astrocytes, microglia, and BDNF in the chronic pain and show that NM treatment, which alleviates neuropathic pain, affects glial cells and BDNF expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Giardini, Aline Carolina& Santos, Fabio Martinez dos& da Silva, Joyce Teixeira& de Oliveira, Mara Evany& Martins, Daniel Oliveira& Chacur, Marucia. 2017. Neural Mobilization Treatment Decreases Glial Cells and Brain-Derived Neurotrophic Factor Expression in the Central Nervous System in Rats with Neuropathic Pain Induced by CCI in Rats. Pain Research and Management،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1197480
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Giardini, Aline Carolina…[et al.]. Neural Mobilization Treatment Decreases Glial Cells and Brain-Derived Neurotrophic Factor Expression in the Central Nervous System in Rats with Neuropathic Pain Induced by CCI in Rats. Pain Research and Management No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1197480
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Giardini, Aline Carolina& Santos, Fabio Martinez dos& da Silva, Joyce Teixeira& de Oliveira, Mara Evany& Martins, Daniel Oliveira& Chacur, Marucia. Neural Mobilization Treatment Decreases Glial Cells and Brain-Derived Neurotrophic Factor Expression in the Central Nervous System in Rats with Neuropathic Pain Induced by CCI in Rats. Pain Research and Management. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1197480
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1197480
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر