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Neural Mobilization Treatment Decreases Glial Cells and Brain-Derived Neurotrophic Factor Expression in the Central Nervous System in Rats with Neuropathic Pain Induced by CCI in Rats
Joint Authors
Giardini, Aline Carolina
Santos, Fabio Martinez dos
da Silva, Joyce Teixeira
de Oliveira, Mara Evany
Martins, Daniel Oliveira
Chacur, Marucia
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-22
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
Glial cells are implicated in the development of chronic pain and brain-derived neurotropic factor (BDNF) released from activated microglia contributes to the nociceptive transmission.
Neural mobilization (NM) technique is a method clinically effective in reducing pain sensitivity.
Here we examined the involvement of glial cells and BDNF expression in the thalamus and midbrain after NM treatment in rats with chronic constriction injury (CCI).
CCI was induced and rats were subsequently submitted to 10 sessions of NM, every other day, beginning 14 days after CCI.
Thalamus and midbrain were analyzed for glial fibrillary acidic protein (GFAP), microglial cell OX-42, and BDNF using Immunohistochemistry and Western blot assays.
Results.
Thalamus and midbrain of CCI group showed increases in GFAP, OX-42, and BDNF expression compared with control group and, in contrast, showed decreases in GFAP, OX-42, and BDNF after NM when compared with CCI group.
The decreased immunoreactivity for GFAP, OX-42, and BDNF in ventral posterolateral nucleus in thalamus and the periaqueductal gray in midbrain was shown by immunohistochemistry.
Conclusions.
These findings may improve the knowledge about the involvement of astrocytes, microglia, and BDNF in the chronic pain and show that NM treatment, which alleviates neuropathic pain, affects glial cells and BDNF expression.
American Psychological Association (APA)
Giardini, Aline Carolina& Santos, Fabio Martinez dos& da Silva, Joyce Teixeira& de Oliveira, Mara Evany& Martins, Daniel Oliveira& Chacur, Marucia. 2017. Neural Mobilization Treatment Decreases Glial Cells and Brain-Derived Neurotrophic Factor Expression in the Central Nervous System in Rats with Neuropathic Pain Induced by CCI in Rats. Pain Research and Management،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1197480
Modern Language Association (MLA)
Giardini, Aline Carolina…[et al.]. Neural Mobilization Treatment Decreases Glial Cells and Brain-Derived Neurotrophic Factor Expression in the Central Nervous System in Rats with Neuropathic Pain Induced by CCI in Rats. Pain Research and Management No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1197480
American Medical Association (AMA)
Giardini, Aline Carolina& Santos, Fabio Martinez dos& da Silva, Joyce Teixeira& de Oliveira, Mara Evany& Martins, Daniel Oliveira& Chacur, Marucia. Neural Mobilization Treatment Decreases Glial Cells and Brain-Derived Neurotrophic Factor Expression in the Central Nervous System in Rats with Neuropathic Pain Induced by CCI in Rats. Pain Research and Management. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1197480
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197480