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Synovial Sarcoma of the Head and Neck: A Single Institution Review
المؤلفون المشاركون
Gopalakrishnan, Vancheswaran
Araujo, Dejka M.
Amini, Behrang
Nowell, Erica N.
Lazar, Alexander J.
Benjamin, Robert S.
Wagner, Michael J.
Lin, Patrick P.
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-06-05
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Background.
The prognosis and clinical characteristics of head and neck synovial sarcomas (HNSS) are unclear.
Herein, we present an update using a cohort of patients treated at our institution.
Methods.
We performed a retrospective chart review of 44 patients diagnosed with primary HNSS between March 1990 and June 2012.
Overall survival (OS) and progression-free survival (PFS) curves were estimated and hazard ratios (HRs) were calculated.
Results.
The entire cohort’s median PFS was 4.6 years, and 20 of the 44 (45%) patients developed either local or distant recurrence.
Tumor size ≥ 5 cm (p=0.008, HR = 4.69; 95% CI = 1.34–16.38) and a primary presentation in the soft tissues of the neck (p=0.04, HR = 2.41; 95% CI = 1.003–5.82) were associated with significantly worse PFS.
The OS and PFS of patients who received definitive local therapy versus those who received additional adjuvant systemic therapy did not differ significantly.
Conclusion.
Despite the treatment challenges associated with HNSS, our cohort of patients had a better prognosis than one might expect in this unfavorable anatomical location.
Our findings suggest that tumor size and site are predictive of PFS and that wide surgical excision is of vital importance, since traditional cytotoxic chemotherapy has limited efficacy at this site.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gopalakrishnan, Vancheswaran& Amini, Behrang& Wagner, Michael J.& Nowell, Erica N.& Lazar, Alexander J.& Lin, Patrick P.…[et al.]. 2017. Synovial Sarcoma of the Head and Neck: A Single Institution Review. Complexity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1197714
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gopalakrishnan, Vancheswaran…[et al.]. Synovial Sarcoma of the Head and Neck: A Single Institution Review. Complexity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1197714
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gopalakrishnan, Vancheswaran& Amini, Behrang& Wagner, Michael J.& Nowell, Erica N.& Lazar, Alexander J.& Lin, Patrick P.…[et al.]. Synovial Sarcoma of the Head and Neck: A Single Institution Review. Complexity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1197714
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1197714
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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