Synovial Sarcoma of the Head and Neck: A Single Institution Review
Joint Authors
Gopalakrishnan, Vancheswaran
Araujo, Dejka M.
Amini, Behrang
Nowell, Erica N.
Lazar, Alexander J.
Benjamin, Robert S.
Wagner, Michael J.
Lin, Patrick P.
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
The prognosis and clinical characteristics of head and neck synovial sarcomas (HNSS) are unclear.
Herein, we present an update using a cohort of patients treated at our institution.
Methods.
We performed a retrospective chart review of 44 patients diagnosed with primary HNSS between March 1990 and June 2012.
Overall survival (OS) and progression-free survival (PFS) curves were estimated and hazard ratios (HRs) were calculated.
Results.
The entire cohort’s median PFS was 4.6 years, and 20 of the 44 (45%) patients developed either local or distant recurrence.
Tumor size ≥ 5 cm (p=0.008, HR = 4.69; 95% CI = 1.34–16.38) and a primary presentation in the soft tissues of the neck (p=0.04, HR = 2.41; 95% CI = 1.003–5.82) were associated with significantly worse PFS.
The OS and PFS of patients who received definitive local therapy versus those who received additional adjuvant systemic therapy did not differ significantly.
Conclusion.
Despite the treatment challenges associated with HNSS, our cohort of patients had a better prognosis than one might expect in this unfavorable anatomical location.
Our findings suggest that tumor size and site are predictive of PFS and that wide surgical excision is of vital importance, since traditional cytotoxic chemotherapy has limited efficacy at this site.
American Psychological Association (APA)
Gopalakrishnan, Vancheswaran& Amini, Behrang& Wagner, Michael J.& Nowell, Erica N.& Lazar, Alexander J.& Lin, Patrick P.…[et al.]. 2017. Synovial Sarcoma of the Head and Neck: A Single Institution Review. Complexity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1197714
Modern Language Association (MLA)
Gopalakrishnan, Vancheswaran…[et al.]. Synovial Sarcoma of the Head and Neck: A Single Institution Review. Complexity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1197714
American Medical Association (AMA)
Gopalakrishnan, Vancheswaran& Amini, Behrang& Wagner, Michael J.& Nowell, Erica N.& Lazar, Alexander J.& Lin, Patrick P.…[et al.]. Synovial Sarcoma of the Head and Neck: A Single Institution Review. Complexity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1197714
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1197714