Interaction Effects of Season of Birth and Cytokine Genes on Schizotypal Traits in the General Population
المؤلفون المشاركون
Alfimova, Margarita V.
Korovaitseva, Galina I.
Lezheiko, Tatyana V.
Golimbet, Vera E.
المصدر
Schizophrenia Research and Treatment
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-31
دولة النشر
مصر
عدد الصفحات
8
التخصصات الرئيسية
الملخص EN
Literature suggests that the effect of winter birth on vulnerability to schizophrenia might be mediated by increased expression of proinflammatory cytokines due to prenatal infection and its inadequate regulation by anti-inflammatory factors.
As the response of the immune system depends on genotype, this study assessed the interaction effects of cytokine genes and season of birth (SOB) on schizotypy measured with the Schizotypal Personality Questionnaire (SPQ-74).
We searched for associations of IL1B rs16944, IL4 rs2243250, and IL-1RN VNTR polymorphisms, SOB, and their interactions with the SPQ-74 total score in a sample of 278 healthy individuals.
A significant effect of the IL4 X SOB interaction was found, p=0.007 and η2=0.028.
We confirmed this effect using an extended sample of 373 individuals.
Homozygotes CC born in winter showed the highest SPQ total score and differed significantly from winter-born T allele carriers, p=0.049.
This difference was demonstrated for cognitive-perceptual and disorganized but not interpersonal dimensions.
The findings are consistent with the hypothesis that the cytokine genes by SOB interaction can influence variability of schizotypal traits in the general population.
The IL4 T allele appeared to have a protective effect against the development of positive and disorganized schizotypal traits in winter-born individuals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Alfimova, Margarita V.& Korovaitseva, Galina I.& Lezheiko, Tatyana V.& Golimbet, Vera E.. 2017. Interaction Effects of Season of Birth and Cytokine Genes on Schizotypal Traits in the General Population. Schizophrenia Research and Treatment،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1198006
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Alfimova, Margarita V.…[et al.]. Interaction Effects of Season of Birth and Cytokine Genes on Schizotypal Traits in the General Population. Schizophrenia Research and Treatment No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1198006
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Alfimova, Margarita V.& Korovaitseva, Galina I.& Lezheiko, Tatyana V.& Golimbet, Vera E.. Interaction Effects of Season of Birth and Cytokine Genes on Schizotypal Traits in the General Population. Schizophrenia Research and Treatment. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1198006
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1198006
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر