Interaction Effects of Season of Birth and Cytokine Genes on Schizotypal Traits in the General Population
Joint Authors
Alfimova, Margarita V.
Korovaitseva, Galina I.
Lezheiko, Tatyana V.
Golimbet, Vera E.
Source
Schizophrenia Research and Treatment
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Literature suggests that the effect of winter birth on vulnerability to schizophrenia might be mediated by increased expression of proinflammatory cytokines due to prenatal infection and its inadequate regulation by anti-inflammatory factors.
As the response of the immune system depends on genotype, this study assessed the interaction effects of cytokine genes and season of birth (SOB) on schizotypy measured with the Schizotypal Personality Questionnaire (SPQ-74).
We searched for associations of IL1B rs16944, IL4 rs2243250, and IL-1RN VNTR polymorphisms, SOB, and their interactions with the SPQ-74 total score in a sample of 278 healthy individuals.
A significant effect of the IL4 X SOB interaction was found, p=0.007 and η2=0.028.
We confirmed this effect using an extended sample of 373 individuals.
Homozygotes CC born in winter showed the highest SPQ total score and differed significantly from winter-born T allele carriers, p=0.049.
This difference was demonstrated for cognitive-perceptual and disorganized but not interpersonal dimensions.
The findings are consistent with the hypothesis that the cytokine genes by SOB interaction can influence variability of schizotypal traits in the general population.
The IL4 T allele appeared to have a protective effect against the development of positive and disorganized schizotypal traits in winter-born individuals.
American Psychological Association (APA)
Alfimova, Margarita V.& Korovaitseva, Galina I.& Lezheiko, Tatyana V.& Golimbet, Vera E.. 2017. Interaction Effects of Season of Birth and Cytokine Genes on Schizotypal Traits in the General Population. Schizophrenia Research and Treatment،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1198006
Modern Language Association (MLA)
Alfimova, Margarita V.…[et al.]. Interaction Effects of Season of Birth and Cytokine Genes on Schizotypal Traits in the General Population. Schizophrenia Research and Treatment No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1198006
American Medical Association (AMA)
Alfimova, Margarita V.& Korovaitseva, Galina I.& Lezheiko, Tatyana V.& Golimbet, Vera E.. Interaction Effects of Season of Birth and Cytokine Genes on Schizotypal Traits in the General Population. Schizophrenia Research and Treatment. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1198006
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1198006