Transcriptional and Genomic Targets of Neural Stem Cells for Functional Recovery after Hemorrhagic Stroke

المؤلفون المشاركون

Feng, Hua
Chen, Yujie
Zhang, Le
Tao, Wenjing

المصدر

Stem Cells International

العدد

المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.

الناشر

Hindawi Publishing Corporation

تاريخ النشر

2017-01-04

دولة النشر

مصر

عدد الصفحات

8

الملخص EN

Hemorrhagic stroke is a life-threatening disease characterized by a sudden rupture of cerebral blood vessels, and it is widely believed that neural cell death occurs after exposure to blood metabolites or subsequently damaged cells.

Neural stem cells (NSCs), which maintain neurogenesis and are found in subgranular zone and subventricular zone, are thought to be an endogenous neuroprotective mechanism for these brain injuries.

However, due to the complexity of NSCs and their microenvironment, current strategies cannot satisfactorily enhance functional recovery after hemorrhagic stroke.

It is well known that transcriptional and genomic pathways play important roles in ensuring the normal functions of NSCs, including proliferation, migration, differentiation, and neural reconnection.

Recently, emerging evidence from the use of new technologies such as next-generation sequencing and transcriptome profiling has provided insight into our understanding of genomic function and regulation of NSCs.

In the present article, we summarize and present the current data on the control of NSCs at both the transcriptional and genomic levels.

Using bioinformatics methods, we sought to predict novel therapeutic targets of endogenous neurogenesis and exogenous NSC transplantation for functional recovery after hemorrhagic stroke, which could also advance our understanding of its pathophysiology.

نمط استشهاد جمعية علماء النفس الأمريكية (APA)

Zhang, Le& Tao, Wenjing& Feng, Hua& Chen, Yujie. 2017. Transcriptional and Genomic Targets of Neural Stem Cells for Functional Recovery after Hemorrhagic Stroke. Stem Cells International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1200959

نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)

Zhang, Le…[et al.]. Transcriptional and Genomic Targets of Neural Stem Cells for Functional Recovery after Hemorrhagic Stroke. Stem Cells International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1200959

نمط استشهاد الجمعية الطبية الأمريكية (AMA)

Zhang, Le& Tao, Wenjing& Feng, Hua& Chen, Yujie. Transcriptional and Genomic Targets of Neural Stem Cells for Functional Recovery after Hemorrhagic Stroke. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1200959

نوع البيانات

مقالات

لغة النص

الإنجليزية

الملاحظات

Includes bibliographical references

رقم السجل

BIM-1200959