Transcriptional and Genomic Targets of Neural Stem Cells for Functional Recovery after Hemorrhagic Stroke
Joint Authors
Feng, Hua
Chen, Yujie
Zhang, Le
Tao, Wenjing
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-04
Country of Publication
Egypt
No. of Pages
8
Abstract EN
Hemorrhagic stroke is a life-threatening disease characterized by a sudden rupture of cerebral blood vessels, and it is widely believed that neural cell death occurs after exposure to blood metabolites or subsequently damaged cells.
Neural stem cells (NSCs), which maintain neurogenesis and are found in subgranular zone and subventricular zone, are thought to be an endogenous neuroprotective mechanism for these brain injuries.
However, due to the complexity of NSCs and their microenvironment, current strategies cannot satisfactorily enhance functional recovery after hemorrhagic stroke.
It is well known that transcriptional and genomic pathways play important roles in ensuring the normal functions of NSCs, including proliferation, migration, differentiation, and neural reconnection.
Recently, emerging evidence from the use of new technologies such as next-generation sequencing and transcriptome profiling has provided insight into our understanding of genomic function and regulation of NSCs.
In the present article, we summarize and present the current data on the control of NSCs at both the transcriptional and genomic levels.
Using bioinformatics methods, we sought to predict novel therapeutic targets of endogenous neurogenesis and exogenous NSC transplantation for functional recovery after hemorrhagic stroke, which could also advance our understanding of its pathophysiology.
American Psychological Association (APA)
Zhang, Le& Tao, Wenjing& Feng, Hua& Chen, Yujie. 2017. Transcriptional and Genomic Targets of Neural Stem Cells for Functional Recovery after Hemorrhagic Stroke. Stem Cells International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1200959
Modern Language Association (MLA)
Zhang, Le…[et al.]. Transcriptional and Genomic Targets of Neural Stem Cells for Functional Recovery after Hemorrhagic Stroke. Stem Cells International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1200959
American Medical Association (AMA)
Zhang, Le& Tao, Wenjing& Feng, Hua& Chen, Yujie. Transcriptional and Genomic Targets of Neural Stem Cells for Functional Recovery after Hemorrhagic Stroke. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1200959
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1200959