![](/images/graphics-bg.png)
Mesenchymal Stem Cells Promoted Lung Wound Repair through Hox A9 during Endotoxemia-Induced Acute Lung Injury
المؤلفون المشاركون
Zhu, Guangfa
Xin, Xi
Yan, Liu
Yan, Huang
Keng, Li
Chunting, Wu
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-03-29
دولة النشر
مصر
عدد الصفحات
8
الملخص EN
Objectives.
Acute lung injury (ALI) is a common clinical critical disease.
Stem cells transplantation is recognized as an effective way to repair injured lung tissues.
The present study was designed to evaluate the effects of mesenchymal stem cells (MSCs) on repair of lung and its mechanism.
Methods.
MSCs carrying GFP were administrated via trachea into wild-type SD rats 4 hours later after LPS administration.
The lung histological pathology and the distribution of MSCs were determined by HE staining and fluorescence microscopy, respectively.
Next, differentially expressed HOX genes were screened by using real-time PCR array and abnormal expression and function of Hox A9 were analyzed in the lung and the cells.
Results.
MSCs promoted survival rate of ALI animals.
The expression levels of multiple HOX genes had obvious changes after MSCs administration and HOX A9 gene increased by 5.94-fold after MSCs administration into ALI animals.
HOX A9 was distributed in endothelial cells and epithelial cells in animal models and overexpression of Hox A9 can promote proliferation and inhibit inflammatory adhesion of MSCs.
Conclusion.
HoxA9 overexpression induced by MSCs may be closely linked with lung repair after endotoxin shock.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xin, Xi& Yan, Liu& Zhu, Guangfa& Yan, Huang& Keng, Li& Chunting, Wu. 2017. Mesenchymal Stem Cells Promoted Lung Wound Repair through Hox A9 during Endotoxemia-Induced Acute Lung Injury. Stem Cells International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1201208
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xin, Xi…[et al.]. Mesenchymal Stem Cells Promoted Lung Wound Repair through Hox A9 during Endotoxemia-Induced Acute Lung Injury. Stem Cells International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1201208
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xin, Xi& Yan, Liu& Zhu, Guangfa& Yan, Huang& Keng, Li& Chunting, Wu. Mesenchymal Stem Cells Promoted Lung Wound Repair through Hox A9 during Endotoxemia-Induced Acute Lung Injury. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1201208
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1201208
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)