Mesenchymal Stem Cells Promoted Lung Wound Repair through Hox A9 during Endotoxemia-Induced Acute Lung Injury
Joint Authors
Zhu, Guangfa
Xin, Xi
Yan, Liu
Yan, Huang
Keng, Li
Chunting, Wu
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-29
Country of Publication
Egypt
No. of Pages
8
Abstract EN
Objectives.
Acute lung injury (ALI) is a common clinical critical disease.
Stem cells transplantation is recognized as an effective way to repair injured lung tissues.
The present study was designed to evaluate the effects of mesenchymal stem cells (MSCs) on repair of lung and its mechanism.
Methods.
MSCs carrying GFP were administrated via trachea into wild-type SD rats 4 hours later after LPS administration.
The lung histological pathology and the distribution of MSCs were determined by HE staining and fluorescence microscopy, respectively.
Next, differentially expressed HOX genes were screened by using real-time PCR array and abnormal expression and function of Hox A9 were analyzed in the lung and the cells.
Results.
MSCs promoted survival rate of ALI animals.
The expression levels of multiple HOX genes had obvious changes after MSCs administration and HOX A9 gene increased by 5.94-fold after MSCs administration into ALI animals.
HOX A9 was distributed in endothelial cells and epithelial cells in animal models and overexpression of Hox A9 can promote proliferation and inhibit inflammatory adhesion of MSCs.
Conclusion.
HoxA9 overexpression induced by MSCs may be closely linked with lung repair after endotoxin shock.
American Psychological Association (APA)
Xin, Xi& Yan, Liu& Zhu, Guangfa& Yan, Huang& Keng, Li& Chunting, Wu. 2017. Mesenchymal Stem Cells Promoted Lung Wound Repair through Hox A9 during Endotoxemia-Induced Acute Lung Injury. Stem Cells International،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1201208
Modern Language Association (MLA)
Xin, Xi…[et al.]. Mesenchymal Stem Cells Promoted Lung Wound Repair through Hox A9 during Endotoxemia-Induced Acute Lung Injury. Stem Cells International No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1201208
American Medical Association (AMA)
Xin, Xi& Yan, Liu& Zhu, Guangfa& Yan, Huang& Keng, Li& Chunting, Wu. Mesenchymal Stem Cells Promoted Lung Wound Repair through Hox A9 during Endotoxemia-Induced Acute Lung Injury. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1201208
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1201208