Malaysian Tualang Honey Inhibits Hydrogen Peroxide-Induced Endothelial Hyperpermeability
المؤلفون المشاركون
Tan, Jun Jie
Devasvaran, Kogilavanee
Ng, Chin Theng
Fong, Lai Yen
Yong, Yoke Keong
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-08-18
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Malaysian Tualang honey (TH) is a known therapeutic honey extracted from the honeycombs of the Tualang tree (Koompassia excelsa) and has been reported for its antioxidant, anti-inflammatory, antiproliferative, and wound healing properties.
However, the possible vascular protective effect of TH against oxidative stress remains unclear.
In this study, the effects of TH on hydrogen peroxide- (H2O2-) elicited vascular hyperpermeability in human umbilical vein endothelial cells (HUVECs) and Balb/c mice were evaluated.
Our data showed that TH concentrations ranging from 0.01% to 1.00% showed no cytotoxic effect to HUVECs.
Induction with 0.5 mM H2O2 was found to increase HUVEC permeability, but the effect was significantly reversed attenuated by TH (p<0.05), of which the permeability with the highest inhibition peaked at 0.1%.
In Balb/c mice, TH (0.5 g/kg-1.5 g/kg) significantly (p<0.05) reduced H2O2 (0.3%)-induced albumin-bound Evans blue leak, in a dose-dependent manner.
Immunofluorescence staining confirmed that TH reduced actin stress fiber formation while increasing cortical actin formation and colocalization of caveolin-1 and β-catenin in HUVECs.
Signaling studies showed that HUVECs pretreated with TH significantly (p<0.05) decreased intracellular calcium release, while sustaining the level of cAMP when challenged with H2O2.
These results suggested that TH could inhibit H2O2-induced vascular hyperpermeability in vitro and in vivo by suppression of adherence junction protein redistribution via calcium and cAMP, which could have a therapeutic potential for diseases related to the increase of both oxidant and vascular permeability.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Devasvaran, Kogilavanee& Tan, Jun Jie& Ng, Chin Theng& Fong, Lai Yen& Yong, Yoke Keong. 2019. Malaysian Tualang Honey Inhibits Hydrogen Peroxide-Induced Endothelial Hyperpermeability. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1202032
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Devasvaran, Kogilavanee…[et al.]. Malaysian Tualang Honey Inhibits Hydrogen Peroxide-Induced Endothelial Hyperpermeability. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-10.
https://search.emarefa.net/detail/BIM-1202032
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Devasvaran, Kogilavanee& Tan, Jun Jie& Ng, Chin Theng& Fong, Lai Yen& Yong, Yoke Keong. Malaysian Tualang Honey Inhibits Hydrogen Peroxide-Induced Endothelial Hyperpermeability. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-10.
https://search.emarefa.net/detail/BIM-1202032
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202032
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر