The Effects of BMP-2, miR-31, miR-106a, and miR-148a on Osteogenic Differentiation of MSCs Derived from Amnion in Comparison with MSCs Derived from the Bone Marrow
المؤلفون المشاركون
Kheolamai, Pakpoom
Manochantr, Sirikul
Tantrawatpan, Chairat
Tantikanlayaporn, Duangrat
Marupanthorn, Kulisara
Sanguanjit, Prakasit
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-19
دولة النشر
مصر
عدد الصفحات
14
الملخص EN
Mesenchymal stromal cells (MSCs) offering valuable anticipations for the treatment of degenerative diseases.
They can be found in many tissues including amnion.
MSCs from amnion (AM-MSCs) can differentiate into osteoblast similar to that of bone marrow-derived MSCs (BM-MSCs).
However, the ability is not much efficient compared to BM-MSCs.
This study aimed to examine the effects of BMP-2 and miRNAs on osteogenic differentiation of AM-MSCs compared to those of BM-MSCs.
The osteogenic differentiation capacity after miRNA treatment was assessed by ALP expression, ALP activity, and osteogenic marker gene expression.
The results showed that the osteogenic differentiation capacity increased after BMP-2 treatment both in AM-MSCs and BM-MSCs.
MiR-31, miR-106a, and miR-148a were downregulated during the osteogenic differentiation.
After transfection with anti-miRNAs, ALP activity and osteogenic genes were increased over the time of differentiation.
The data lead to the potential for using AM-MSCs as an alternative source for bone regeneration.
Moreover, the information of miRNA expression and function during osteogenic differentiation may be useful for the development of new therapeutics or enhanced an in vitro culture technique required for stem cell-based therapies in the bone regeneration.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Manochantr, Sirikul& Marupanthorn, Kulisara& Tantrawatpan, Chairat& Kheolamai, Pakpoom& Tantikanlayaporn, Duangrat& Sanguanjit, Prakasit. 2017. The Effects of BMP-2, miR-31, miR-106a, and miR-148a on Osteogenic Differentiation of MSCs Derived from Amnion in Comparison with MSCs Derived from the Bone Marrow. Stem Cells International،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1202051
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Manochantr, Sirikul…[et al.]. The Effects of BMP-2, miR-31, miR-106a, and miR-148a on Osteogenic Differentiation of MSCs Derived from Amnion in Comparison with MSCs Derived from the Bone Marrow. Stem Cells International No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1202051
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Manochantr, Sirikul& Marupanthorn, Kulisara& Tantrawatpan, Chairat& Kheolamai, Pakpoom& Tantikanlayaporn, Duangrat& Sanguanjit, Prakasit. The Effects of BMP-2, miR-31, miR-106a, and miR-148a on Osteogenic Differentiation of MSCs Derived from Amnion in Comparison with MSCs Derived from the Bone Marrow. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1202051
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202051
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر