Maternal Adaptive Immune Cells in Decidua Parietalis Display a More Activated and Coinhibitory Phenotype Compared to Decidua Basalis
المؤلفون المشاركون
Tiblad, Eleonor
Lundell, Anna-Carin
Gidlöf, Sebastian
Solders, Martin
Gorchs, Laia
Kaipe, Helen
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-11-29
دولة النشر
مصر
عدد الصفحات
15
الملخص EN
The maternal part of the placenta, the decidua, consists of maternal immune cells, decidual stromal cells, and extravillous fetal trophoblasts.
In a successful pregnancy, these cell compartments interact to provide an intricate balance between fetal tolerance and antimicrobial defense.
These processes are still poorly characterized in the two anatomically different decidual tissues, basalis and parietalis.
We examined immune cells from decidua basalis and parietalis from term placentas (n=15) with flow cytometry.
By using multivariate discriminant analysis, we found a clear separation between the two decidual compartments based on the 81 investigated parameters.
Decidua parietalis lymphocytes displayed a more activated phenotype with a higher expression of coinhibitory markers than those isolated from basalis and contained higher frequencies of T regulatory cells.
Decidua basalis contained higher proportions of monocytes, B cells, and mucosal-associated invariant T (MAIT) cells.
The basalis B cells were more immature, and parietalis MAIT cells showed a more activated phenotype.
Conventional T cells, NK cells, and MAIT cells from both compartments potently responded with the production of interferon-γ and/or cytotoxic molecules in response to stimulation.
To conclude, leukocytes in decidua basalis and parietalis displayed remarkable phenotypic disparities, indicating that the corresponding stromal microenvironments provide different immunoregulatory signals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Solders, Martin& Gorchs, Laia& Gidlöf, Sebastian& Tiblad, Eleonor& Lundell, Anna-Carin& Kaipe, Helen. 2017. Maternal Adaptive Immune Cells in Decidua Parietalis Display a More Activated and Coinhibitory Phenotype Compared to Decidua Basalis. Stem Cells International،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1202209
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Solders, Martin…[et al.]. Maternal Adaptive Immune Cells in Decidua Parietalis Display a More Activated and Coinhibitory Phenotype Compared to Decidua Basalis. Stem Cells International No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1202209
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Solders, Martin& Gorchs, Laia& Gidlöf, Sebastian& Tiblad, Eleonor& Lundell, Anna-Carin& Kaipe, Helen. Maternal Adaptive Immune Cells in Decidua Parietalis Display a More Activated and Coinhibitory Phenotype Compared to Decidua Basalis. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1202209
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202209
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر