Maternal Adaptive Immune Cells in Decidua Parietalis Display a More Activated and Coinhibitory Phenotype Compared to Decidua Basalis
Joint Authors
Tiblad, Eleonor
Lundell, Anna-Carin
Gidlöf, Sebastian
Solders, Martin
Gorchs, Laia
Kaipe, Helen
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-29
Country of Publication
Egypt
No. of Pages
15
Abstract EN
The maternal part of the placenta, the decidua, consists of maternal immune cells, decidual stromal cells, and extravillous fetal trophoblasts.
In a successful pregnancy, these cell compartments interact to provide an intricate balance between fetal tolerance and antimicrobial defense.
These processes are still poorly characterized in the two anatomically different decidual tissues, basalis and parietalis.
We examined immune cells from decidua basalis and parietalis from term placentas (n=15) with flow cytometry.
By using multivariate discriminant analysis, we found a clear separation between the two decidual compartments based on the 81 investigated parameters.
Decidua parietalis lymphocytes displayed a more activated phenotype with a higher expression of coinhibitory markers than those isolated from basalis and contained higher frequencies of T regulatory cells.
Decidua basalis contained higher proportions of monocytes, B cells, and mucosal-associated invariant T (MAIT) cells.
The basalis B cells were more immature, and parietalis MAIT cells showed a more activated phenotype.
Conventional T cells, NK cells, and MAIT cells from both compartments potently responded with the production of interferon-γ and/or cytotoxic molecules in response to stimulation.
To conclude, leukocytes in decidua basalis and parietalis displayed remarkable phenotypic disparities, indicating that the corresponding stromal microenvironments provide different immunoregulatory signals.
American Psychological Association (APA)
Solders, Martin& Gorchs, Laia& Gidlöf, Sebastian& Tiblad, Eleonor& Lundell, Anna-Carin& Kaipe, Helen. 2017. Maternal Adaptive Immune Cells in Decidua Parietalis Display a More Activated and Coinhibitory Phenotype Compared to Decidua Basalis. Stem Cells International،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1202209
Modern Language Association (MLA)
Solders, Martin…[et al.]. Maternal Adaptive Immune Cells in Decidua Parietalis Display a More Activated and Coinhibitory Phenotype Compared to Decidua Basalis. Stem Cells International No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1202209
American Medical Association (AMA)
Solders, Martin& Gorchs, Laia& Gidlöf, Sebastian& Tiblad, Eleonor& Lundell, Anna-Carin& Kaipe, Helen. Maternal Adaptive Immune Cells in Decidua Parietalis Display a More Activated and Coinhibitory Phenotype Compared to Decidua Basalis. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1202209
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202209