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High Sensitivity of Human Adipose Stem Cells to Differentiate into Myofibroblasts in the Presence of C. aspersa Egg Extract
المؤلفون المشاركون
Alvarez-Mon, Melchor
Ortega, Miguel A
Buján, Julia
García-Honduvilla, Natalio
Cifuentes, Alberto
Delgado, Arancha
González, Salvador
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-12-27
دولة النشر
مصر
عدد الصفحات
9
الملخص EN
Introduction.
Regeneration therapy using adipose-derived stem cells (ADSC) has been proposed in the treatment of skin aging.
Myofibroblast plays a relevant role in the organization of the extracellular matrix of the damaged skin.
A natural extract was derived from the eggs of the mollusk Cryptomphalus aspersa (e-CAF) that seems to play a role on skin repair.
We have investigated the potential effects of e-CAF in the differentiation of ADSC.
Materials and methods.
ADSC were cultured in the absence or presence of e-CAF (50 and 200 μg/mL) for 24 hours and 7 days.
Real-time cell assay, morphological, immunofluorescence, and RT-PCR techniques were used to evaluate the cell culture and expression of αSMA, collagen I, and tropoelastin.
Results.
e-CAF induced significant reduction in the rate of growth of ADSC from 24 hours to 7 days of culture.
e-CAF also induced bigger sizes, higher levels of cytoplasmic refringence and complexity, and a more polyhedral morphological changes in the cultured ADSC.
The protein and mRNA expression of αSMA was significantly increased in e-CAF-cultured ADSC.
Conclusion.
e-CAF promotes ADSC differentiation to myofibroblasts and should be considered as a potential agent for the prevention and treatment of skin aging.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
García-Honduvilla, Natalio& Cifuentes, Alberto& Ortega, Miguel A& Delgado, Arancha& González, Salvador& Buján, Julia…[et al.]. 2017. High Sensitivity of Human Adipose Stem Cells to Differentiate into Myofibroblasts in the Presence of C. aspersa Egg Extract. Stem Cells International،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1202334
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
García-Honduvilla, Natalio…[et al.]. High Sensitivity of Human Adipose Stem Cells to Differentiate into Myofibroblasts in the Presence of C. aspersa Egg Extract. Stem Cells International No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1202334
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
García-Honduvilla, Natalio& Cifuentes, Alberto& Ortega, Miguel A& Delgado, Arancha& González, Salvador& Buján, Julia…[et al.]. High Sensitivity of Human Adipose Stem Cells to Differentiate into Myofibroblasts in the Presence of C. aspersa Egg Extract. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1202334
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202334
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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