Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent
المؤلفون المشاركون
Đorović, Jelena
Dimitrić Marković, Jasmina M.
Marković, Zoran
Dimić, Dušan S.
Avdović, Edina H.
Petrović, Isidora P.
Stanisavljević, Danijela D.
Stevanović, Milena J.
Potočňák, Ivan
Samoľová, Erika
Trifunović, Srećko R.
Saso, Luciano
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-02-13
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The newly synthesized coumarin derivative with dopamine, 3-(1-((3,4-dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione, was completely structurally characterized by X-ray crystallography.
It was shown that several types of hydrogen bonds are present, which additionally stabilize the structure.
The compound was tested in vitro against different cell lines, healthy human keratinocyte HaCaT, cervical squamous cell carcinoma SiHa, breast carcinoma MCF7, and hepatocellular carcinoma HepG2.
Compared to control, the new derivate showed a stronger effect on both healthy and carcinoma cell lines, with the most prominent effect on the breast carcinoma MCF7 cell line.
The molecular docking study, obtained for ten different conformations of the new compound, showed its inhibitory nature against CDKS protein.
Lower inhibition constant, relative to one of 4-OH-coumarine, proved stronger and more numerous interactions with CDKS protein.
These interactions were carefully examined for both parent molecule and derivative and explained from a structural point of view.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Dimić, Dušan S.& Marković, Zoran& Saso, Luciano& Avdović, Edina H.& Đorović, Jelena& Petrović, Isidora P.…[et al.]. 2019. Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1202493
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Dimić, Dušan S.…[et al.]. Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1202493
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Dimić, Dušan S.& Marković, Zoran& Saso, Luciano& Avdović, Edina H.& Đorović, Jelena& Petrović, Isidora P.…[et al.]. Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1202493
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202493
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر