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Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent
Joint Authors
Đorović, Jelena
Dimitrić Marković, Jasmina M.
Marković, Zoran
Dimić, Dušan S.
Avdović, Edina H.
Petrović, Isidora P.
Stanisavljević, Danijela D.
Stevanović, Milena J.
Potočňák, Ivan
Samoľová, Erika
Trifunović, Srećko R.
Saso, Luciano
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2019, Issue 2019 (31 Dec. 2019), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2019-02-13
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The newly synthesized coumarin derivative with dopamine, 3-(1-((3,4-dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione, was completely structurally characterized by X-ray crystallography.
It was shown that several types of hydrogen bonds are present, which additionally stabilize the structure.
The compound was tested in vitro against different cell lines, healthy human keratinocyte HaCaT, cervical squamous cell carcinoma SiHa, breast carcinoma MCF7, and hepatocellular carcinoma HepG2.
Compared to control, the new derivate showed a stronger effect on both healthy and carcinoma cell lines, with the most prominent effect on the breast carcinoma MCF7 cell line.
The molecular docking study, obtained for ten different conformations of the new compound, showed its inhibitory nature against CDKS protein.
Lower inhibition constant, relative to one of 4-OH-coumarine, proved stronger and more numerous interactions with CDKS protein.
These interactions were carefully examined for both parent molecule and derivative and explained from a structural point of view.
American Psychological Association (APA)
Dimić, Dušan S.& Marković, Zoran& Saso, Luciano& Avdović, Edina H.& Đorović, Jelena& Petrović, Isidora P.…[et al.]. 2019. Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent. Oxidative Medicine and Cellular Longevity،Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1202493
Modern Language Association (MLA)
Dimić, Dušan S.…[et al.]. Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent. Oxidative Medicine and Cellular Longevity No. 2019 (2019), pp.1-12.
https://search.emarefa.net/detail/BIM-1202493
American Medical Association (AMA)
Dimić, Dušan S.& Marković, Zoran& Saso, Luciano& Avdović, Edina H.& Đorović, Jelena& Petrović, Isidora P.…[et al.]. Synthesis and Characterization of 3-(1-((3,4-Dihydroxyphenethyl)amino)ethylidene)-chroman-2,4-dione as a Potential Antitumor Agent. Oxidative Medicine and Cellular Longevity. 2019. Vol. 2019, no. 2019, pp.1-12.
https://search.emarefa.net/detail/BIM-1202493
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202493