Microarray Analysis Reveals a Potential Role of lncRNA Expression in 3,4-BenzopyreneAngiotensin II-Activated Macrophage in Abdominal Aortic Aneurysm
المؤلفون المشاركون
Xue, Yang-jing
Ji, Kangting
Shen, Yegen
Wu, Shao-ze
Tao, Lu-yuan
Wang, Jiao-ni
Huang, Kai-yu
Zhou, Yingying
Fang, Aili
Wang, Jie
Wang, Jinsheng
Pan, Lulu
Li, Lei
المصدر
العدد
المجلد 2017، العدد 2017 (31 ديسمبر/كانون الأول 2017)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2017-10-18
دولة النشر
مصر
عدد الصفحات
11
الملخص EN
Abdominal aortic aneurysm (AAA) is a fatal disease, and exposure to 3,4-benzopyrene (Bap) is closely related to the development of AAA.
We have found that Bap could impair the biological function of endothelial progenitor cells (EPCs), which are associated with the occurrence of AAA.
We have also demonstrated that macrophage activation plays a key role in Bap-induced AAA, but the mechanism is unknown.
Here, we used a mouse lncRNA array to investigate the expression signatures of lncRNAs and mRNAs in Bap-activated macrophage.
A total of 457 lncRNAs and 219 mRNAs were found to be differentially expressed.
The function of differential mRNAs was determined by pathway and Gene Ontology analysis.
Eight pathways associated with inflammation were upregulated, and seven pathways including cell apoptosis were downregulated.
It was worth noting that AGE-RAGE pathway, which was involved in Bap-induced EPC dysfunction, was significantly upregulated in Bap-activated macrophage and may contribute to AAA formation.
Thus, lncRNAs may exert a key role in activated macrophages and intervene the core lncRNAs and may inhibit the occurrence of a series of cascade reactions in the macrophages, which may provide potential targets for AAA caused by smoking.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Yingying& Wang, Jiao-ni& Xue, Yang-jing& Fang, Aili& Wu, Shao-ze& Huang, Kai-yu…[et al.]. 2017. Microarray Analysis Reveals a Potential Role of lncRNA Expression in 3,4-BenzopyreneAngiotensin II-Activated Macrophage in Abdominal Aortic Aneurysm. Stem Cells International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1202496
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Yingying…[et al.]. Microarray Analysis Reveals a Potential Role of lncRNA Expression in 3,4-BenzopyreneAngiotensin II-Activated Macrophage in Abdominal Aortic Aneurysm. Stem Cells International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1202496
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Yingying& Wang, Jiao-ni& Xue, Yang-jing& Fang, Aili& Wu, Shao-ze& Huang, Kai-yu…[et al.]. Microarray Analysis Reveals a Potential Role of lncRNA Expression in 3,4-BenzopyreneAngiotensin II-Activated Macrophage in Abdominal Aortic Aneurysm. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1202496
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1202496
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر