Microarray Analysis Reveals a Potential Role of lncRNA Expression in 3,4-BenzopyreneAngiotensin II-Activated Macrophage in Abdominal Aortic Aneurysm
Joint Authors
Xue, Yang-jing
Ji, Kangting
Shen, Yegen
Wu, Shao-ze
Tao, Lu-yuan
Wang, Jiao-ni
Huang, Kai-yu
Zhou, Yingying
Fang, Aili
Wang, Jie
Wang, Jinsheng
Pan, Lulu
Li, Lei
Source
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-18
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Abdominal aortic aneurysm (AAA) is a fatal disease, and exposure to 3,4-benzopyrene (Bap) is closely related to the development of AAA.
We have found that Bap could impair the biological function of endothelial progenitor cells (EPCs), which are associated with the occurrence of AAA.
We have also demonstrated that macrophage activation plays a key role in Bap-induced AAA, but the mechanism is unknown.
Here, we used a mouse lncRNA array to investigate the expression signatures of lncRNAs and mRNAs in Bap-activated macrophage.
A total of 457 lncRNAs and 219 mRNAs were found to be differentially expressed.
The function of differential mRNAs was determined by pathway and Gene Ontology analysis.
Eight pathways associated with inflammation were upregulated, and seven pathways including cell apoptosis were downregulated.
It was worth noting that AGE-RAGE pathway, which was involved in Bap-induced EPC dysfunction, was significantly upregulated in Bap-activated macrophage and may contribute to AAA formation.
Thus, lncRNAs may exert a key role in activated macrophages and intervene the core lncRNAs and may inhibit the occurrence of a series of cascade reactions in the macrophages, which may provide potential targets for AAA caused by smoking.
American Psychological Association (APA)
Zhou, Yingying& Wang, Jiao-ni& Xue, Yang-jing& Fang, Aili& Wu, Shao-ze& Huang, Kai-yu…[et al.]. 2017. Microarray Analysis Reveals a Potential Role of lncRNA Expression in 3,4-BenzopyreneAngiotensin II-Activated Macrophage in Abdominal Aortic Aneurysm. Stem Cells International،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1202496
Modern Language Association (MLA)
Zhou, Yingying…[et al.]. Microarray Analysis Reveals a Potential Role of lncRNA Expression in 3,4-BenzopyreneAngiotensin II-Activated Macrophage in Abdominal Aortic Aneurysm. Stem Cells International No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1202496
American Medical Association (AMA)
Zhou, Yingying& Wang, Jiao-ni& Xue, Yang-jing& Fang, Aili& Wu, Shao-ze& Huang, Kai-yu…[et al.]. Microarray Analysis Reveals a Potential Role of lncRNA Expression in 3,4-BenzopyreneAngiotensin II-Activated Macrophage in Abdominal Aortic Aneurysm. Stem Cells International. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1202496
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1202496